Details of Microbe Species (MIC)

General Information of MIC (ID: MC0937)
  MIC Name
Prevotella spp.
  Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Negative
  Host Relationship
Commensal
  No. of Coding Genes
4114
  No. of Non-Coding Genes
58
  No. of Small Non-Coding Genes
58
  No. of Gene Transcripts
4172
  Description
Prevotella is a genus of gram-negative bacteria. Prevotella spp. are members of the oral, vaginal, and gut microbiota and are often recovered from anaerobic infections of the respiratory tract. These infections include aspiration pneumonia, lung abscess, pulmonary empyema, and chronic otitis media and sinusitis.
  External Links Taxonomy ID 838
GutMDisorder ID gm0535
Genome Assembly ID Bilophila_sp_4_1_30_V1

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Microbial cell components
           Metabolite Name: Lipopolysaccharide Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial cell components
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT3A EM Info . . . [1], [2]
DNA Methylation DNMT3B EM Info . . . [1], [2]
DNA Methylation DNMT1 EM Info Oral epithelial cells . Periodontitis [2], [3]
Histone Acetylation H4 EM Info . . . [1], [2]
Histone Acetylation Histone EM Info TGF-beta1 cells lysine 9 . [2], [4]
Histone Acetylation H3 EM Info Oral epithelial cells lysine 9 Periodontitis [2], [3]
Histone Deacetylation HDAC6 EM Info . . . [1], [2]
Histone Deacetylation HDAC7 EM Info . . . [1], [2]
Histone Phosphorylation Histone EM Info TGF-beta1 cells serine 10 . [2], [4]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
3 Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.
4 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.

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