Details of Microbe Species (MIC)

General Information of MIC (ID: MC0932)
  MIC Name
Bacteroides dorei
  Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Negative
  Host Relationship
Commensal
  Genome Size (bp)
5243219
  Description
Bacteroides dorei are gram-negative bacteria that are anaerobic rods.
  External Links Taxonomy ID 357276
GutMDisorder ID gm0081
Genome Assembly ID ASM15607v1
GOLD Database ID Go0003531
GIMICA ID MIC00154

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [1], [2]
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [1], [2]
     Molecule Type: Microbial cell components
           Metabolite Name: Lipopolysaccharide Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial cell components
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT3A EM Info . . . [3], [4]
DNA Methylation DNMT3B EM Info . . . [3], [4]
DNA Methylation DNMT1 EM Info Oral epithelial cells . Periodontitis [4], [5]
Histone Acetylation H4 EM Info . . . [3], [4]
Histone Acetylation Histone EM Info TGF-beta1 cells lysine 9 . [4], [6]
Histone Acetylation H3 EM Info Oral epithelial cells lysine 9 Periodontitis [4], [5]
Histone Deacetylation HDAC6 EM Info . . . [3], [4]
Histone Deacetylation HDAC7 EM Info . . . [3], [4]
Histone Phosphorylation Histone EM Info TGF-beta1 cells serine 10 . [4], [6]


References
1 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
2 Species Deletions from Microbiome Consortia Reveal Key Metabolic Interactions between Gut Microbes mSystems. 2019 Jul 16;4(4):e00185-19. doi: 10.1128/mSystems.00185-19.
3 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
4 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
5 Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.
6 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.

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