Details of Microbe Species (MIC)

General Information of MIC (ID: MC0855)
  MIC Name
Lactococcus lactis
  Synonym
Bacterium lactis
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Lactococcus
  Oxygen Sensitivity
Facultative anaerobe
  Microbial Metabolism
Saccharolytic; Respiratory or Fermentative
  Gram
Positive
  Genome Size (bp)
2365589
  No. of Coding Genes
2197
  No. of Non-Coding Genes
80
  No. of Small Non-Coding Genes
80
  No. of Gene Transcripts
2277
  No. of Base Pairs
2398091
  Description
Lactococcus lactis is a facultative anaerobic, gram-positive non-sporulating and non-motile bacteria.
  External Links Taxonomy ID 1358
GutMDisorder ID gm0415
Genome Assembly ID ASM76111v1
GOLD Database ID Go0034085
GIMICA ID MIC00745

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Vitamins
           Metabolite Name: Folate (B9) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Methylation H3K27 EM Info . Hes1 promoter . [1], [2]
Histone Methylation H3K27 EM Info . Neurog2 promoter . [1], [2]
miRNA miR-10A EM Info . . . [1], [2]
miRNA miR-149-5p EM Info HL-7702 cells . Normal [1], [3]
miRNA miR-22-3p EM Info HL-7702 cells . Normal [4], [2]
miRNA miR-149-5p EM Info QGY-7703 cells . Cancerous [4], [2]
miRNA miR-22-3p EM Info QGY-7703 cells . Cancerous [5], [6]
           Metabolite Name: Pyridoxine (B6) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation Mlh1 EM Info Lymphocytes promoter Colon and rectal cancer [4], [2]
           Metabolite Name: Riboflavin (B2) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation Zac1 EM Info . . . [4], [2]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Riboflavin production in Lactococcus lactis: potential for in situ production of vitamin-enriched foods Appl Environ Microbiol. 2004 Oct;70(10):5769-77. doi: 10.1128/AEM.70.10.5769-5777.2004.
3 Real-Time Detection of Riboflavin Production by Lactobacillus plantarum Strains and Tracking of Their Gastrointestinal Survival and Functionality in vitro and in vivo Using mCherry Labeling Front Microbiol. 2019 Jul 31;10:1748. doi: 10.3389/fmicb.2019.01748. eCollection 2019.
4 Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes. PLoS One. 2017 Jan 3;12(1):e0168049. doi: 10.1371/journal.pone.0168049. eCollection 2017.
5 Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer. Carcinogenesis. 2008 Sep;29(9):1765-73. doi: 10.1093/carcin/bgn074. Epub 2008 Mar 13.
6 Biosynthesis of Vitamins by Probiotic Bacteria.

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