Details of Microbe Species (MIC)

General Information of MIC (ID: MC0333)
  MIC Name
Clostridium sordellii ATCC 9714
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Peptostreptococcaceae
Genus: Paeniclostridium
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Positive
  Genome Size (bp)
3552922
  Description
Clostridium sordellii ATCC 9714 is a strain of obligate anaerobic, gram-positive, saccharolytic bacteria.
  External Links Taxonomy ID 1292036

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Methionine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Hypermethylation DNMT3A EM Info Blood cells . . [1], [2]
Histone Trimethylation H3 EM Info Blood cells lysine 4 . [1], [2]
miRNA miR-328-3p EM Info . . . [3], [2]
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [4], [2]
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [5], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [5], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [6], [2]
Histone Acetylation H3K56 EM Info HepG2 cells ACACA promoter Hypoxia [7], [2]
Histone Acetylation H3K9 EM Info HepG2 cells FASN promoter Hypoxia [8], [2]
Histone Acetylation H3K9 EM Info HepG2 cells VEGF promoter Hypoxia [2], [9]
Histone Acetylation H3K27 EM Info HepG2 cells VEGF promoter Hypoxia [2], [10]
Histone Acetylation H3K56 EM Info HepG2 cells VEGF promoter Hypoxia [2], [10]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K56 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells ACACA promoter Hypoxia [11], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [5], [2]
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [3], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [3], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [3], [2]
Histone Acetylation H3K9 EM Info KGN cells GPR41 . [3], [2]
Histone Acetylation H3K9 EM Info KGN cells GPR43 . [3], [2]
Histone Deacetylation HDAC2 EM Info . . . [3], [2]
Histone Deacetylation HDAC1 EM Info . . . [3], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [3], [2]
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [2], [9]
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [4], [2]


References
1 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
3 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
4 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
6 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
7 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
8 Hydrogen sulfide signaling in regulation of cell behaviors. Nitric Oxide. 2020 Oct 1;103:9-19. doi: 10.1016/j.niox.2020.07.002. Epub 2020 Jul 17.
9 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
10 Dysregulation of methionine metabolism in multiple sclerosis. Neurochem Int. 2018 Jan;112:1-4. doi: 10.1016/j.neuint.2017.10.011. Epub 2017 Oct 26.
11 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.

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