Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10025)
  Official Symbol
SIRT1
  Official Full Name
sirtuin 1
  Molecule Type
Protein coding
  Position On Chromosome
chr10(Start:67884656 - End:67918390)
  Strand
+
  Uniprot Entry
Q96EB6 
  ENSG ID
ENSG00000096717 
  Dnmivd Disease
KIRC 
    Disease Relevance (Click to Show/Hide)
         1C62: Human immunodeficiency virus disease without mention of tuberculosis or malaria Acquired immune deficiency syndrome [Human immunodeficiency virus disease without mention of tuberculosis or malaria]
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         2A00: Primary neoplasms of brain Glioma [Primary neoplasms of brain]
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         2A01: Primary neoplasms of meninges Meningioma [Primary neoplasms of meninges]
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         2A90: Mature T-cell lymphoma, specified types, nodal or systemic Anaplastic large cell lymphoma (ALCL) [Mature T-cell lymphoma, specified types, nodal or systemic]
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         2B6B: Malignant neoplasms of nasopharynx Nasopharyngeal carcinoma (NPC) [Malignant neoplasms of nasopharynx]
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         2B70: Malignant neoplasms of oesophagus Barrett's esophagus and esophageal adenocarcinoma [Malignant neoplasms of oesophagus]
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         2B70: Malignant neoplasms of oesophagus Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus]
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         2B72: Malignant neoplasms of stomach Gastric cancer [Malignant neoplasms of stomach]
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         2B80: Malignant neoplasms of small intestine Small intestinal neuroendocrine tumours (SINETs) [Malignant neoplasms of small intestine]
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         2B90: Malignant neoplasms of colon Colorectal cancer [Malignant neoplasms of colon]
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         2C10: Malignant neoplasm of pancreas Pancreatic ductal adenocarcinoma (PDAC) [Malignant neoplasm of pancreas]
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         2C12: Malignant neoplasms of liver or intrahepatic bile ducts Liver cancer [Malignant neoplasms of liver or intrahepatic bile ducts]
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         2C25: Malignant neoplasms of bronchus or lung Lung cancer [Malignant neoplasms of bronchus or lung]
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         2C25: Malignant neoplasms of bronchus or lung Non small cell lung cancer (NSCLC) [Malignant neoplasms of bronchus or lung]
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         2C25: Malignant neoplasms of bronchus or lung Lung adenocarcinoma [Malignant neoplasms of bronchus or lung]
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         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
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         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
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         2C82: Malignant neoplasms of prostate Prostate cancer [Malignant neoplasms of prostate]
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         2D10: Malignant neoplasms of thyroid gland Thyroid tumors [Malignant neoplasms of thyroid gland]
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         2E66: Carcinoma in situ of cervix uteri Cervical intraepithelial neoplasia [Carcinoma in situ of cervix uteri]
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         4A40: Lupus erythematosus Systemic lupus erythematosus (SLE) [Lupus erythematosus]
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         4A80: Allergic or hypersensitivity disorders involving the respiratory tract Respiratory allergy [Allergic or hypersensitivity disorders involving the respiratory tract]
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         4A85: Complex allergic or hypersensitivity conditions Food allergy [Complex allergic or hypersensitivity conditions]
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         5A80: Ovarian dysfunction Polycystic ovarian syndrome (PCOS) [Ovarian dysfunction]
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         5B81: Obesity Obesity [Obesity]
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         6A00: Disorders of intellectual development Intellectual disability and congenital anomalies(ID/CA) [Disorders of intellectual development]
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         6A02: Autism spectrum disorder Autism [Autism spectrum disorder]
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         6A20: Schizophrenia Schizophrenia [Schizophrenia]
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         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
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         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
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         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
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         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
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         9A01: Infectious disorders of eyelid Human eye and its diseases [Infectious disorders of eyelid]
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         BD40: Atherosclerotic chronic arterial occlusive disease Atherosclerosis [Atherosclerotic chronic arterial occlusive disease]
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         CA22: Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) [Chronic obstructive pulmonary disease]
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         CA23: Asthma Asthma [Asthma]
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         DD70: Crohn disease Crohn's disease [Crohn disease]
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         DD71: Ulcerative colitis Ulcerative colitis [Ulcerative colitis]
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         FA20: Rheumatoid arthritis Rheumatoid arthritis [Rheumatoid arthritis]
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         FA21: Psoriatic arthritis Psoriatic [Psoriatic arthritis]
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         GA10: Endometriosis Endometriosis [Endometriosis]
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         JA24: Pre-eclampsia Preeclampsia (PE) [Pre-eclampsia]
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         KA21: Disorders of newborn related to short gestation or low birth weight Preterm birth [Disorders of newborn related to short gestation or low birth weight]
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         LA02: Spina bifida Neural tube defects (NTDs) [Spina bifida]
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         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
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         LD40: Complete trisomies of the autosomes Down syndrome (DS) [Complete trisomies of the autosomes]
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         LD44: Deletions of the autosomes Deletion or duplication of chromosome 7q11.23 [Deletions of the autosomes]
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         SD86: Dementia disorder Dementia [Dementia disorder]
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         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XB8M: Congenital Melanoma [Congenital]
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         XH0945: Squamous cell carcinoma Head and neck squamous cell cancer (HNSCC) [Squamous cell carcinoma]
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         XH1E13: Germinoma Germinoma [Germinoma]
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         XH1XF3: Osteosarcoma Osteosarcoma [Osteosarcoma]
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         XH3DV3: Adenoma Adenoma [Adenoma]
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         XH4546: Signet ring cell carcinoma Signet ring cell colorectal cancer [Signet ring cell carcinoma]
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         XH46F1: Clear cell renal cell carcinoma Clear cell renal cell carcinoma (ccRCC) [Clear cell renal cell carcinoma]
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         XH4KH2: Adrenal cortical carcinoma Adrenal cortical cancer [Adrenal cortical carcinoma]
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         XH4S92: Leukaemia Leukemia [Leukaemia]
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         XH4W48: Hepatocellular carcinoma Hepatocellular carcinoma (HCC) [Hepatocellular carcinoma]
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         XH68V1: Liver cell adenoma Hepatocellular adenoma [Liver cell adenoma]
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         XH6PH6: Astrocytoma Astrocytoma [Astrocytoma]
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         XH7F82: Glioblastoma Glioblastoma [Glioblastoma]
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         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia]
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         XH7ZQ4: Atypical teratoid/rhabdoid tumour Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour]
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         XH85Z0: Neuroblastoma Neuroblastoma [Neuroblastoma]
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         XH8AA5: Acute myeloid leukaemia Acute myeloid leukemia (AML) [Acute myeloid leukaemia]
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         XH8P29: Medulloblastoma Primary medulloblastoma [Medulloblastoma]
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         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
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         XH8SH6: CNS embryonal tumour Primitive neuroectodermal tumors [CNS embryonal tumour]
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         XH94U0: Pituitary adenoma Nonfunctioning pituitary adenomas [Pituitary adenoma]
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         XH9HQ1: Gastrointestinal stromal tumour Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour]
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         XN487: Human immunodeficiency virus Human immunodeficiency virus (HIV) [Human immunodeficiency virus]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid has been shown to increased sirtuin deacetylase (SIRT1) deacetylation activity.
  Metabolite Name: Spermine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Spermine could increase the expression levels of SIRT1 in HT1080 cells.
  Metabolite Name: Conjugated linoleic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [4]
     Description
Conjugated linoleic acid has been shown to increased sirtuin deacetylase (SIRT1) deacetylation activity.
  Metabolite Name: Linoleic acid derivative
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [4]
     Description
Linoleic acid derivative has been shown to increased sirtuin deacetylase (SIRT1) deacetylation activity.
  Metabolite Name: Hydrogen sulfide (H2S)
     Detailed Information Meta Info click to show the detail information of this Metabolite [5], [6]
     Description
Hydrogen sulfide (H2S) has been shown to up-regulate the expression of sirtuin (SIRT) 1.
  Metabolite Name: Spermidine
     Detailed Information Meta Info click to show the detail information of this Metabolite [7], [8]
     Description
Spermidine could increase the expression levels of sirtuin 1 (SIRT1).
  Metabolite Name: beta-glucan
     Detailed Information Meta Info click to show the detail information of this Metabolite [9]
     Description
beta-glucan has been shown to inhibite the expression of Sirtuin1 (histone deacetylases).

References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
3 Activation of p53 by spermine mediates induction of autophagy in HT1080 cells. Int J Biol Macromol. 2014 Feb;63:56-63. doi: 10.1016/j.ijbiomac.2013.10.041. Epub 2013 Nov 1.
4 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
5 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
6 Lactate-utilizing community is associated with gut microbiota dysbiosis in colicky infants Sci Rep. 2017 Sep 11;7(1):11176. doi: 10.1038/s41598-017-11509-1.
7 Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs. Int J Biol Macromol. 2012 Dec;51(5):1003-7. doi: 10.1016/j.ijbiomac.2012.08.013. Epub 2012 Aug 25.
8 Stages of pregnancy and weaning influence the gut microbiota diversity and function in sows J Appl Microbiol. 2019 Sep;127(3):867-879. doi: 10.1111/jam.14344. Epub 2019 Jul 1.
9 mTOR-and HIF-1-alpha-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 2014 Sep 26;345(6204):1250684. doi: 10.1126/science.1250684.

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