Details of Microbe Species (MIC)

General Information of MIC (ID: MC1107)
  MIC Name
Legionella pneumophila
  Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Legionellales
Family: Legionellaceae
Genus: Legionella
  Oxygen Sensitivity
Obligate aerobe
  Microbial Metabolism
Saccharolytic; Respiratory
  Gram
Negative
  Host Relationship
Pathogen
  Genome Size (bp)
3785576
  No. of Base Pairs
3470989
  Description
Legionella pneumophila is a thin, aerobic, pleomorphic, flagellated, non-spore-forming, gram-negative bacteria of the genus Legionella.
  External Links Taxonomy ID 446
GOLD Database ID Go0501396
GIMICA ID MIC00751

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Microbial cell components
           Metabolite Name: Flagellin Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial cell components
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K14 EM Info A549 cells IL-8 promoter . [1]
Histone Acetylation H4 EM Info A549 cells IL-8 promoter . [1]
Histone Deacetylation HDAC1 EM Info Lung epithelial cells . . [1]
Histone Deacetylation HDAC5 EM Info Lung epithelial cells . . [1]
Histone Phosphorylation H3S10 EM Info A549 cells IL-8 promoter . [1]

Full List of Protein(s) Produced by This MIC
     Protein Type: .
           Protein Name: LegAS4 Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Methylation H3 EM Info 293T cells lysine 4 . [2]
     Protein Type: Microbial secreted proteins
           Protein Name: RomA Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3 EM Info THP-1 cells lysine 14 Legionella pneumophila infection [3]
Histone Trimethylation H3K14 EM Info THP-1 cells CXCL1 promoter Legionella pneumophila infection [3]
Histone Trimethylation H3K14 EM Info THP-1 cells CXCL2 promoter Legionella pneumophila infection [3]

References
1 Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression J Immunol. 2008 Jul 15;181(2):940-7. doi: 10.4049/jimmunol.181.2.940.
2 SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription EMBO Rep. 2013 Aug;14(8):733-40. doi: 10.1038/embor.2013.86. Epub 2013 Jun 25.
3 Legionella pneumophila effector RomA uniquely modifies host chromatin to repress gene expression and promote intracellular bacterial replication Cell Host Microbe. 2013 Apr 17;13(4):395-405. doi: 10.1016/j.chom.2013.03.004.

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