Details of Microbe Species (MIC)

General Information of MIC (ID: MC1060)
  MIC Name
Lactobacillus reuteri 6475
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Limosilactobacillus
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Fermentative
  Gram
Positive
  Host Relationship
Commensal
  Description
Lactobacillus reuteri is a lactic acid bacteria found in a variety of natural environments, including the gastrointestinal tract of humans and other animals. It does not appear to be pathogenic and may have health effects.
  External Links Taxonomy ID 1598

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Ethionine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Ethylation H3 EM Info THP-1 cells lysine 36 . [1], [2]
Histone Ethylation H3 EM Info THP-1 cells lysine 9 . [3], [4]
Histone Trimethylation H3K9 EM Info Blastocysts Nanog . [1], [2]
Histone Trimethylation H3K9 EM Info Blastocysts Tead4 . [1], [2]
     Molecule Type: Vitamins
           Metabolite Name: Folate (B9) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation MLH1 EM Info Serum CpG site . [3]
DNA Methylation p16 EM Info Serum CpG site . [3]
DNA Methylation MGMT EM Info Serum CpG site . [2], [5]
Histone Methylation H3K27 EM Info . Hes1 promoter . [3], [4]
Histone Methylation H3K27 EM Info . Neurog2 promoter . [6], [2]
miRNA miR-22-3p EM Info QGY-7703 cells . Cancerous [2], [5]
miRNA miR-149-5p EM Info QGY-7703 cells . Cancerous [2], [5]
miRNA miR-10A EM Info . . . [6], [2]
miRNA miR-22-3p EM Info HL-7702 cells . Normal [6], [2]
miRNA miR-149-5p EM Info HL-7702 cells . Normal [6], [2]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
3 Two-carbon folate cycle of commensal Lactobacillus reuteri 6475 gives rise to immunomodulatory ethionine, a source for histone ethylation. FASEB J. 2019 Mar;33(3):3536-3548. doi: 10.1096/fj.201801848R. Epub 2018 Nov 19.
4 Methionine-dependent histone methylation at developmentally important gene loci in mouse preimplantation embryos. J Nutr Biochem. 2015 Dec;26(12):1664-9. doi: 10.1016/j.jnutbio.2015.08.009. Epub 2015 Aug 20.
5 High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans. Clin Epigenetics. 2017 Jul 24;9:74. doi: 10.1186/s13148-017-0374-y. eCollection 2017.
6 Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes. PLoS One. 2017 Jan 3;12(1):e0168049. doi: 10.1371/journal.pone.0168049. eCollection 2017.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.