Details of Microbe Species (MIC)

General Information of MIC (ID: MC0797)
  MIC Name
Ruminococcus torques
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Lachnospiraceae
Genus: Mediterraneibacter
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Positive
  Host Relationship
Commensal
  Genome Size (bp)
2739406
  Description
Ruminococcus torques is an obligately anaerobic, gram-negative, non-motile and non-spore forming bacteria. Ruminococcus torques was associated with severity of bowel symptoms.
  External Links Taxonomy ID 33039
GutMDisorder ID gm0594
Genome Assembly ID ASM15392v1
GOLD Database ID Go0000919
GIMICA ID MIC01142

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [1], [2]
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [3], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [4], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [5], [2]
Histone Crotonylation H3K9 EM Info KGN cells GPR43 . [4], [2]
Histone Deacetylation HDAC1 EM Info . . . [5], [6]
Histone Deacetylation HDAC2 EM Info . . . [5], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [7], [2]


References
1 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.
2 Formate Promotes Shigella Intercellular Spread and Virulence Gene Expression mBio. 2018 Sep 25;9(5):e01777-18. doi: 10.1128/mBio.01777-18.
3 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
4 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
6 p-Cresyl Sulfate. Toxins (Basel). 2017 Jan 29;9(2):52. doi: 10.3390/toxins9020052.
7 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.

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