Details of Microbe Species (MIC)

General Information of MIC (ID: MC0771)
  MIC Name
Roseburia inulinivorans
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Roseburia
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative; Convert acetate
  Gram
Negative
  Host Relationship
Commensal
  Genome Size (bp)
3781127
  No. of Coding Genes
3442
  No. of Non-Coding Genes
64
  No. of Small Non-Coding Genes
64
  No. of Gene Transcripts
3506
  No. of Base Pairs
3781127
  Description
Roseburia inulinivorans is a bacteria first isolated from human faeces. It is anaerobic, gram-positive or gram-variable, slightly curved rod-shaped and motile.
  External Links Taxonomy ID 360807
GutMDisorder ID gm0575
Genome Assembly ID RIL183
GOLD Database ID Go0003376
GIMICA ID MIC01119

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [1], [2]
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation POU5F1 EM Info iPS cells promoter . [3], [2]
DNA Demethylation DPPA2 EM Info iPS cells promoter . [4], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [5], [2]
Histone Crotonylation H3K9 EM Info KGN cells GPR43 . [1], [2]
Histone Deacetylation HDAC1 EM Info . . . [5], [6]
Histone Deacetylation HDAC2 EM Info . . . [5], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [7], [8]
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [9], [2]
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [7], [8]


References
1 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
2 The composition and metabolism of faecal microbiota is specifically modulated by different dietary polysaccharides and mucin: an isothermal microcalorimetry study Benef Microbes. 2018 Jan 29;9(1):21-34. doi: 10.3920/BM2016.0198. Epub 2017 Oct 12.
3 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
4 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
6 p-Cresyl Sulfate. Toxins (Basel). 2017 Jan 29;9(2):52. doi: 10.3390/toxins9020052.
7 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
8 Microbiota in anorexia nervosa: The triangle between bacterial species, metabolites and psychological tests PLoS One. 2017 Jun 21;12(6):e0179739. doi: 10.1371/journal.pone.0179739. eCollection 2017.
9 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.