Details of Microbe Species (MIC)

General Information of MIC (ID: MC0770)
  MIC Name
Eubacterium rectale
  Synonym
Bacteroides rectalis
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative; Convert acetate
  Gram
Positive
  Host Relationship
Commensal
  Genome Size (bp)
3449685
  No. of Coding Genes
2860
  No. of Non-Coding Genes
59
  No. of Small Non-Coding Genes
59
  No. of Gene Transcripts
2919
  No. of Base Pairs
3045135
  Description
Eubacteria rectale is one of the most prevalent human gut bacteria, but its diversity and population genetics are not well understood because large-scale whole-genome investigations of this microbe have not been carried out.
  External Links Taxonomy ID 39491
GutMDisorder ID gm0316
Genome Assembly ID T1815
GOLD Database ID Go0001428
GIMICA ID MIC00578

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [1], [2]
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [3], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [4], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [5], [2]
Histone Crotonylation H3K9 EM Info KGN cells GPR43 . [4], [2]
Histone Deacetylation HDAC1 EM Info . . . [5], [6]
Histone Deacetylation HDAC2 EM Info . . . [5], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [7], [2]


References
1 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.
2 The composition and metabolism of faecal microbiota is specifically modulated by different dietary polysaccharides and mucin: an isothermal microcalorimetry study Benef Microbes. 2018 Jan 29;9(1):21-34. doi: 10.3920/BM2016.0198. Epub 2017 Oct 12.
3 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
4 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
6 p-Cresyl Sulfate. Toxins (Basel). 2017 Jan 29;9(2):52. doi: 10.3390/toxins9020052.
7 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.

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