Details of Microbe Species (MIC)

General Information of MIC (ID: MC0748)
  MIC Name
Saccharomyces cerevisiae
  Synonym
Mycoderma cerevisiae
  Lineage Kingdom: Eukaryota
Phylum: Ascomycota
Class: Saccharomycetes
Order: Saccharomycetales
Family: Saccharomycetaceae
Genus: Saccharomyces
  Oxygen Sensitivity
Facultative anaerobe
  Microbial Metabolism
Fermentative
  Host Relationship
Probiotic
  Description
Saccharomyces cerevisiae is a species of yeast. The species has been instrumental in winemaking, baking, and brewing since ancient times. It is the microorganism behind the most common type of fermentation.
  External Links Taxonomy ID 4932
Genome Assembly ID ASM308665v1
GOLD Database ID Go0019361
GIMICA ID MIC01145

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [1], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [1], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [3], [4]
Histone Crotonylation H3K9 EM Info KGN cells GPR43 . [1], [2]
Histone Deacetylation HDAC2 EM Info . . . [5], [4]
Histone Deacetylation HDAC1 EM Info . . . [5], [4]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [6], [4]
     Molecule Type: Other metabolites
           Metabolite Name: S-Adenosyl Methionine (SAM) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA hypermethylation ASB7 EM Info HT-29 cells Cg20072001 Colorectal carcinoma [1], [2]
DNA hypermethylation MIR636 EM Info HT-29 cells Cg21028463 Colorectal carcinoma [1], [2]
DNA hypermethylation SLC39A6 EM Info HT-29 cells Cg04447424 Colorectal carcinoma [1], [2]
DNA Hypomethylation HAAO EM Info SW480 cells Cg08421126 Colorectal carcinoma [1], [2]
DNA Hypomethylation CRISPLD1 EM Info HT-29 cells Cg15953602 Colorectal carcinoma [1], [2]
DNA Hypomethylation DTX1 EM Info HT-29 cells Cg22685245 Colorectal carcinoma [1], [2]
DNA Hypomethylation MYOCD EM Info HT-29 cells Cg20062401 Colorectal carcinoma [1], [2]
DNA Hypomethylation CYP4F22 EM Info HT-29 cells Cg24456663 Colorectal carcinoma [1], [2]
DNA Hypomethylation GATA4 EM Info HT-29 cells Cg14900471 Colorectal carcinoma [1], [2]
DNA Hypomethylation PAK7 EM Info HT-29 cells Cg22457984 Colorectal carcinoma [1], [2]
DNA Hypomethylation SNORA49 EM Info HT-29 cells Cg07588358 Colorectal carcinoma [1], [2]
DNA Hypomethylation TAL1 EM Info SW480 cells Cg11432900 Colorectal carcinoma [1], [2]
DNA Hypomethylation TAL1 EM Info SW480 cells Cg11766986 Colorectal carcinoma [1], [2]
DNA Hypomethylation TSPAN11 EM Info HT-29 cells Cg20372004 Colorectal carcinoma [7], [4]
DNA Hypomethylation TP53INP1 EM Info HT-29 cells Cg13393036 Colorectal carcinoma [8], [4]
DNA Hypomethylation SEZ6L EM Info HT-29 cells Cg09983462 Colorectal carcinoma [8], [4]
Histone Methylation H3K4 EM Info RAW 264.7 cells TNF-alpha promoter . [9], [2]


References
1 S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression. Cells. 2020 Aug 9;9(8):1864. doi: 10.3390/cells9081864.
2 Progress in the microbial production of S-adenosyl-L-methionine World J Microbiol Biotechnol. 2016 Sep;32(9):153. doi: 10.1007/s11274-016-2102-8. Epub 2016 Jul 27.
3 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
4 Polyphasic Characterization of Yeasts and Lactic Acid Bacteria Metabolic Contribution in Semi-Solid Fermentation of Chinese Baijiu (Traditional Fermented Alcoholic Drink): Towards the Design of a Tailored Starter Culture Microorganisms. 2019 May 25;7(5):147. doi: 10.3390/microorganisms7050147.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
6 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
7 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.
8 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
9 S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation. Hepatology. 2008 May;47(5):1655-66. doi: 10.1002/hep.22231.

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