Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10069)
  Official Symbol
SIRT4
  Official Full Name
Sirtuin 4
  Synonym
SIR2L4
  Molecule Type
Protein coding
  Position On Chromosome
chr12(Start:120302316 - End:120313249)
  Strand
+
  Uniprot Entry
Q9Y6E7 
  ENSG ID
ENSG00000089163 
  Dnmivd Disease
BLCA 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Folate (B9)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Folate (B9) has been shown to inhibite sirtuins (Class III HDAC).
  Metabolite Name: Vitamin K
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Vitamin K has been shown to inhibite sirtuins (Class III HDAC).
  Metabolite Name: Thiamine (B1)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Thiamine (B1) has been shown to inhibite sirtuins (Class III HDAC).
  Metabolite Name: Pyridoxine (B6)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [4]
     Description
Pyridoxine (B6) has been shown to inhibite sirtuins (Class III HDAC).
  Metabolite Name: Pantothenic acid (B5)
     Detailed Information Meta Info click to show the detail information of this Metabolite [5], [1]
     Description
Pantothenic acid (B5) has been shown to inhibite sirtuins (Class III HDAC).

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3. Hum Mol Genet. 2013 Jul 1;22(13):2662-75. doi: 10.1093/hmg/ddt115. Epub 2013 Mar 7.
4 Lysine-specific demethylase 1 activation by vitamin B2 attenuates efficacy of apatinib for proliferation and migration of gastric cancer cell MGC-803. J Cell Biochem. 2018 Jun;119(6):4957-4966. doi: 10.1002/jcb.26741. Epub 2018 Mar 9.
5 Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes. PLoS One. 2017 Jan 3;12(1):e0168049. doi: 10.1371/journal.pone.0168049. eCollection 2017.

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