Drug Information

Drug General Information
Drug ID
D06EWG
Former ID
DNC003012
Drug Name
Formic Acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467777]
Formula
CHO2-
InChI
InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1
InChIKey
BDAGIHXWWSANSR-UHFFFAOYSA-M
CAS Number
CAS 64-18-6
PubChem Compound ID
283
PubChem Substance ID
2203, 2712, 841549, 4668969, 8143755, 8150550, 10533692, 14709153, 24438659, 50073763, 50817872, 57320099, 92729992, 92741270, 103036860, 104042951, 104294385, 126406823, 126687287, 127497873, 135269870, 137002191, 142323754, 160644736, 160644737, 160644738, 163218836, 178101261, 223444138, 223444139, 223749098
Target and Pathway
Target(s) 3-phosphoshikimate1-carboxyvinyltransferase Target Info Inhibitor [551393]
Mannose-6-phosphate isomerase Target Info Inhibitor [551393]
Nitric-oxide synthase, brain Target Info Inhibitor [551393]
Hypoxanthine-guanine phosphoribosyltransferase Target Info Inhibitor [551393]
Carbonic anhydrase II Target Info Inhibitor [551393]
Delta-aminolevulinic acid dehydratase Target Info Inhibitor [551393]
Peptide deformylase Target Info Inhibitor [551393]
Heme oxygenase Target Info Inhibitor [551393]
Glutathione S-transferase Target Info Inhibitor [551393]
Heparin-binding growth factor1 Target Info Inhibitor [551393]
BioCyc Pathway Citrulline-nitric oxide cyclePWY-5920:Heme biosynthesis
Tetrapyrrole biosynthesisPWY-5874:Heme degradationPWY66-374:C20 prostanoid biosynthesis
KEGG Pathway Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
Phagosome
Circadian entrainment
Long-term depression
Salivary secretion
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)hsa00230:Purine metabolism
Drug metabolism - other enzymes
Metabolic pathwayshsa00910:Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretionhsa00860:Porphyrin and chlorophyll metabolism
Metabolic pathwayshsa00860:Porphyrin and chlorophyll metabolism
HIF-1 signaling pathway
Mineral absorption
MicroRNAs in cancerhsa00590:Arachidonic acid metabolism
Metabolic pathwayshsa04010:MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Hippo signaling pathway
Regulation of actin cytoskeleton
Pathways in cancer
Melanoma
NetPath Pathway EGFR1 Signaling PathwayNetPath_16:IL4 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway CCKR signaling map STP02746:Heme biosynthesisP00005:Angiogenesis
FGF signaling pathway
Pathway Interaction Database Validated transcriptional targets of AP1 family members Fra1 and Fra2
HIF-1-alpha transcription factor networkfgf_pathway:FGF signaling pathway
PathWhiz Pathway Arginine and Proline MetabolismPW000052:Purine MetabolismPW000158:Porphyrin MetabolismPW000158:Porphyrin Metabolism
Reactome ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclaseR-HSA-74217:Purine salvageR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxideR-HSA-917937:Iron uptake and transportR-HSA-109704:PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade
Phospholipase C-mediated cascade
Phospholipase C-mediated cascade
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
WikiPathways Monoamine Transport
Myometrial Relaxation and Contraction Pathways
Amyotrophic lateral sclerosis (ALS)
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Alzheimers Disease
Effects of Nitric Oxide
Serotonin Transporter ActivityWP404:Nucleotide Metabolism
Mesodermal Commitment Pathway
Endoderm Differentiation
Metabolism of nucleotidesWP2770:Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP561:Heme Biosynthesis
Metabolism of porphyrinsWP408:Oxidative Stress
Transcriptional activation by NRF2
NRF2 pathway
Nuclear Receptors Meta-Pathway
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP2650:Arachidonic acid metabolism
Aryl Hydrocarbon Receptor
Integrated Pancreatic Cancer PathwayWP51:Regulation of Actin Cytoskeleton
Differentiation Pathway
Hair Follicle Development: Organogenesis (Part 2 of 3)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PIP3 activates AKT signaling
Integrated Pancreatic Cancer Pathway
Signaling by FGFR
References
Ref 467777(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4540).
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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