Target Information

Target General Infomation
Target ID
T34287
Former ID
TTDS00450
Target Name
Mannose-6-phosphate isomerase
Gene Name
PMI1
Synonyms
PMI; Phosphohexomutase; Phosphomannose isomerase; PMI1
Target Type
Successful
Disease Acne vulgaris [ICD9: 706.1; ICD10: L70.0]
Leprosy and dermatitis herpetiformis [ICD10: L13.0]
Function
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
BioChemical Class
Intramolecular oxidoreductases
Target Validation
T34287
UniProt ID
P34948
EC Number
EC 5.3.1.8
Sequence
MSSEKLFRIQCGYQNYDWGKIGSSSAVAQFVHNSDPSITIDETKPYAELWMGTHPSVPSK
AIDLNNQTLRDLVTAKPQEYLGESIITKFGSSKELPFLFKVLSIEKVLSIQAHPDKKLGA
QLHAADPKNYPDDNHKPEMAIAVTDFEGFCGFKPLDQLAKTLATVPELNEIIGQELVDEF
ISGIKLPAEVGSQDDVNNRKLLQKVFGKLMNTDDDVIKQQTAKLLERTDREPQVFKDIDS
RLPELIQRLNKQFPNDIGLFCGCLLLNHVGLNKGEAMFLQAKDPHAYISGDIIECMAASD
NVVRAGFTPKFKDVKNLVEMLTYSYESVEKQKMPLQEFPRSKGDAVKSVLYDPPIAEFSV
LQTIFDKSKGGKQVIEGLNGPSIVIATNGKGTIQITGDDSTKQKIDTGYVFFVAPGSSIE
LTADSANQDQDFTTYRAFVEA
Drugs and Mode of Action
Drug(s) Sulfacetamide Drug Info Approved Acne vulgaris [538335], [551871]
Sulfoxone Drug Info Approved Leprosy and dermatitis herpetiformis [551871]
Inhibitor Acetate Ion Drug Info [551393]
Formic Acid Drug Info [551393]
GNF-PF-2272 Drug Info [531262]
GNF-PF-5134 Drug Info [531262]
NSC-66209 Drug Info [531262]
Sulfacetamide Drug Info [536712]
Sulfoxone Drug Info [536712]
References
Ref 538335FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 080028.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 531262Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2).
Ref 536712Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives. Met Based Drugs. 2000;7(1):49-54.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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