Target Information

Target General Infomation
Target ID
T46365
Former ID
TTDR00116
Target Name
M-phase inducer phosphatase 2
Gene Name
CDC25B
Synonyms
Cdc25B phosphatase; Dual specificity phosphatase Cdc25B; CDC25B
Target Type
Discontinued
Disease Cancer [ICD9: 140-229; ICD10: C00-C96]
Function
Functionsas a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates cdc2 and activate its kinase activity.
BioChemical Class
Phosphoric monoester hydrolases
Target Validation
T46365
UniProt ID
P30305
EC Number
EC 3.1.3.48
Sequence
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMH
DLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMD
PHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEA
GSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPD
RKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKT
LEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQ
QEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETM
VALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKR
VILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQ
DYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
Drugs and Mode of Action
Drug(s) MX-7065 Drug Info Terminated Cancer [547465]
Inhibitor 3-isopropyl-4-(phenylamino)naphthalene-1,2-dione Drug Info [527986]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione Drug Info [527986]
3-isopropyl-4-phenylnaphthalene-1,2-dione Drug Info [527986]
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione Drug Info [527986]
4-ethoxynaphthalene-1,2-dione Drug Info [529817]
5,6,7,8-tetrahydroanthracene-1,4-dione Drug Info [529817]
6,7-dibromoquinoline-5,8-dione Drug Info [529691]
ADOCIAQUINONE B Drug Info [529691]
ANTHRAQUINONE Drug Info [529817]
Beta-Mercaptoethanol Drug Info [551393]
Cysteine Sulfenic Acid Drug Info [551391]
Cysteinesulfonic Acid Drug Info [551393]
Double Oxidized Cysteine Drug Info [551393]
JUGLONE Drug Info [529817]
Methyl Mercury Ion Drug Info [551393]
MX-7065 Drug Info [551830]
NSC-95397 Drug Info [529691]
Pathways
KEGG Pathway MAPK signaling pathway
Cell cycle
Progesterone-mediated oocyte maturation
MicroRNAs in cancer
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Wnt Signaling Pathway
Pathway Interaction Database PLK1 signaling events
FOXM1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Aurora A signaling
Reactome Cyclin B2 mediated events
Cyclin A/B1 associated events during G2/M transition
Cdk2-associated events at S phase entry
WikiPathways Senescence and Autophagy in Cancer
MAPK Signaling Pathway
Retinoblastoma (RB) in Cancer
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Mitotic G2-G2/M phases
Cell Cycle
References
Ref 547465Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016615)
Ref 527986Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
Ref 529691Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. Epub 2008 Aug 7.Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.
Ref 529817Bioorg Med Chem. 2009 Mar 15;17(6):2276-81. Epub 2008 Nov 8.Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.
Ref 551391DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551830Handbook of Assay Development in Drug Discovery, Lisa K. Minor, 2013. Page(11).

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