Drug Information

Drug General Information
Drug ID
D08GWQ
Former ID
DNC006430
Drug Name
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527986]
Formula
C19H16O2S
Canonical SMILES
CC(C)C1=C(C2=CC=CC=C2C(=O)C1=O)SC3=CC=CC=C3
InChI
1S/C19H16O2S/c1-12(2)16-18(21)17(20)14-10-6-7-11-15(14)19(16)22-13-8-4-3-5-9-13/h3-12H,1-2H3
InChIKey
VHVWQYNOEGPBOE-UHFFFAOYSA-N
PubChem Compound ID
44409669
Target and Pathway
Target(s) M-phase inducer phosphatase 2 Target Info Inhibitor [527986]
M-phase inducer phosphatase 1 Target Info Inhibitor [527986]
mRNA of Protein tyrosine phosphatase-1B Target Info Inhibitor [527986]
KEGG Pathway MAPK signaling pathway
Cell cycle
Progesterone-mediated oocyte maturation
MicroRNAs in cancerhsa04110:Cell cycle
MicroRNAs in cancerhsa04520:Adherens junction
Insulin signaling pathway
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Wnt Signaling PathwayNetPath_16:IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_25:FSH Signaling Pathway
PANTHER Pathway Cadherin signaling pathway
Pathway Interaction Database PLK1 signaling events
FOXM1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Aurora A signalinge2f_pathway:E2F transcription factor network
ATR signaling pathway
Validated targets of C-MYC transcriptional activation
ATM pathwayinsulin_pathway:Insulin Pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Signaling events mediated by PTP1B
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by TCPTP
IGF1 pathway
EGF receptor (ErbB1) signaling pathway
Posttranslational regulation of adherens junction stability and dissassembly
PDGFR-beta signaling pathway
N-cadherin signaling events
Reactome Cyclin B2 mediated events
Cyclin A/B1 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entryR-HSA-113510:E2F mediated regulation of DNA replication
G0 and Early G1
Polo-like kinase mediated events
Activation of ATR in response to replication stress
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Cyclin A:Cdk2-associated events at S phase entryR-HSA-354192:Integrin alphaIIb beta3 signaling
Regulation of IFNG signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
WikiPathways Senescence and Autophagy in Cancer
MAPK Signaling Pathway
Retinoblastoma (RB) in Cancer
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Mitotic G2-G2/M phases
Cell CycleWP707:DNA Damage Response
G1 to S cell cycle control
S Phase
ATM Signaling Pathway
Mitotic G1-G1/S phases
Cell Cycle
Cell Cycle Checkpoints
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage ResponseWP481:Insulin Signaling
Growth hormone receptor signaling
Leptin signaling pathway
Interferon gamma signaling
Interferon alpha/beta signaling
Integrin alphaIIb beta3 signaling
References
Ref 527986Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
Ref 527986Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8. Epub 2006 Jan 24.Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.

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