Drug Information

Drug General Information
Drug ID
D02UHP
Former ID
DNC009363
Drug Name
6,7-dibromoquinoline-5,8-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529691]
Formula
C9H3Br2NO2
Canonical SMILES
C1=CC2=C(C(=O)C(=C(C2=O)Br)Br)N=C1
InChI
1S/C9H3Br2NO2/c10-5-6(11)9(14)7-4(8(5)13)2-1-3-12-7/h1-3H
InChIKey
CPZKOUMVYNIHQE-UHFFFAOYSA-N
PubChem Compound ID
255964
Target and Pathway
Target(s) M-phase inducer phosphatase 2 Target Info Inhibitor [529691]
KEGG Pathway MAPK signaling pathway
Cell cycle
Progesterone-mediated oocyte maturation
MicroRNAs in cancer
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Wnt Signaling Pathway
Pathway Interaction Database PLK1 signaling events
FOXM1 transcription factor network
p38 signaling mediated by MAPKAP kinases
Aurora A signaling
Reactome Cyclin B2 mediated events
Cyclin A/B1 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
WikiPathways Senescence and Autophagy in Cancer
MAPK Signaling Pathway
Retinoblastoma (RB) in Cancer
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Mitotic G2-G2/M phases
Cell Cycle
References
Ref 529691Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. Epub 2008 Aug 7.Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.
Ref 529691Bioorg Med Chem. 2008 Oct 1;16(19):9040-9. Epub 2008 Aug 7.Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties.

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