Details of Microbe Species (MIC)

General Information of MIC (ID: MC1276)
  MIC Name
Bilophila spp.
  Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Deltaproteobacteria
Order: Desulfovibrionales
Family: Desulfovibrionaceae
Genus: Bilophila
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Anaerobic respiration
  Gram
Negative
  Host Relationship
Commensal
  Description
Bilophila is a gram-negative anaerobic bacteria that belongs in the Proteobacteria phylum.
  External Links Taxonomy ID 35832
GutMDisorder ID gm0115
Genome Assembly ID ASM1836812v1

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Other metabolites
           Metabolite Name: Hydrogen sulfide (H2S) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation Foxp3 EM Info Treg cells Promoter Adoptive transfer colitis [1], [2]
DNA Methylation AT1b EM Info Inflammatory cells Genbank:U01033 277-1454 Hypertension [1], [3]
DNA Methylation DNMT1 EM Info HUVECs . . [1], [4]
DNA Methylation DNMT3A EM Info Smooth muscle cells . . [1], [5]
DNA Methylation TFAM EM Info Smooth muscle cells promoter: 210 bp and30 bp . [1], [5]
Histone Acetylation H3 EM Info THP-1 cells IL-6 promoter Inflammation [1], [6]
Histone Acetylation H3 EM Info THP-1 cells TNF-Alpha promoter Inflammation [1], [6]
Histone Deacetylation SIRT3 EM Info Cardiomyocytes . Myocardial hypertrophy [1], [7]
Histone Deacetylation HDAC EM Info THP-1 cells . Inflammation [1], [6]
Histone Deacetylation SIRT1 EM Info A549 cells . Mitochondrial dysfunction [1], [8]
Histone Methylation H3K27 EM Info THP-1 cells IL-6 promoter Inflammation [1], [6]
Histone Methylation H3K27 EM Info THP-1 cells TNF-Alpha promoter Inflammation [1], [6]
Histone Methylation H3K9 EM Info THP-1 cells IL-6 promoter Inflammation [1], [6]
Histone Methylation H3K9 EM Info THP-1 cells TNF-Alpha promoter Inflammation [1], [6]
miRNA miR-126-3p EM Info HUVECs . . [1], [4]
miRNA miR-129 EM Info Glomerular endothelial cells . Hypertension [1], [9]
miRNA miR-194 EM Info Glomerular endothelial cells . Genetic diabetic kidney [1], [10]
miRNA miR-455 EM Info BEAS-2B cells . Hypoxic injury [1], [11]


References
1 Dietary nutrients shape gut microbes and intestinal mucosa via epigenetic modifications. Crit Rev Food Sci Nutr. 2020 Oct 12:1-15. doi: 10.1080/10408398.2020.1828813. Online ahead of print.
2 Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis. Immunity. 2015 Aug 18;43(2):251-63. doi: 10.1016/j.immuni.2015.07.017. Epub 2015 Aug 11.
3 Maternal Renovascular Hypertensive Rats Treatment With Hydrogen Sulfide Increased the Methylation of AT1b Gene in Offspring. Am J Hypertens. 2017 Nov 6;30(12):1220-1227. doi: 10.1093/ajh/hpx124.
4 Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p. Am J Physiol Cell Physiol. 2020 May 1;318(5):C857-C869. doi: 10.1152/ajpcell.00406.2019. Epub 2020 Mar 18.
5 Hydrogen Sulfide Maintains Mitochondrial DNA Replication via Demethylation of TFAM. Antioxid Redox Signal. 2015 Sep 1;23(7):630-42. doi: 10.1089/ars.2014.6186. Epub 2015 May 14.
6 Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling. Int J Mol Med. 2015 Jun;35(6):1741-6. doi: 10.3892/ijmm.2015.2176. Epub 2015 Apr 8.
7 Hydrogen sulfide signaling in regulation of cell behaviors. Nitric Oxide. 2020 Oct 1;103:9-19. doi: 10.1016/j.niox.2020.07.002. Epub 2020 Jul 17.
8 Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1. Aging (Albany NY). 2019 Dec 23;11(24):11844-11864. doi: 10.18632/aging.102454. Epub 2019 Dec 23.
9 Hydrogen sulfide alleviates hypertensive kidney dysfunction through an epigenetic mechanism. Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H874-H885. doi: 10.1152/ajpheart.00637.2016. Epub 2017 Feb 17.
10 GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney. Sci Rep. 2017 Sep 7;7(1):10924. doi: 10.1038/s41598-017-11256-3.
11 Involvement of miR-455 in the protective effect of H(2)S against chemical hypoxia-induced injury in BEAS-2B cells. Pathol Res Pract. 2018 Nov;214(11):1804-1810. doi: 10.1016/j.prp.2018.08.008. Epub 2018 Aug 16.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.