Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10053)
  Official Symbol
FOXP3
  Official Full Name
forkhead box P3
  Synonym
AIID;DIETER;IPEX;JM2;PIDX;SCURFIN;XPID
  Molecule Type
Protein coding
  Position On Chromosome
chrx(Start:49250438 - End:49270477)
  Strand
-
  Uniprot Entry
Q9BZS1 
  ENSG ID
ENSG00000049768 
  Dnmivd Disease
BRCA 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Hydrogen sulfide (H2S)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Hydrogen sulfide (H2S) has been shown to hypermethylation of Foxp3 through reducing Tet1 and Tet2 expression.

References
1 Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling. Int J Mol Med. 2015 Jun;35(6):1741-6. doi: 10.3892/ijmm.2015.2176. Epub 2015 Apr 8.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.

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