Details of Microbe Species (MIC)

General Information of MIC (ID: MC1253)
  MIC Name
Gordonibacter urolithinfaciens
  Synonym
Gordonibacter faecihominis, Gordonibacter sp. ResAG-26, Gordonibacter sp. ResAG-43, Gordonibacter sp. ResAG-5
  Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Coriobacteriia
Order: Eggerthellales
Family: Eggerthellaceae
Genus: Gordonibacter
  Description
Gordonibacter urolithinfaciens was isolated from human feces and is able to metabolize ellagic acid (a dietary phenolic compound present in various fruits) to urolithins.
  External Links Taxonomy ID 1335613
Genome Assembly ID ASM967819v1

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Coumarins and derivatives
           Metabolite Name: urolithin A Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K9 EM Info U937 cells gp91-phox promoter . [1], [2]
Histone Acetylation HAT EM Info THP-1 cells . . [1], [2]
           Metabolite Name: urolithin B Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation HAT EM Info THP-1 cells . . [1], [2]
           Metabolite Name: urolithin C Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation HAT EM Info THP-1 cells . . [2], [3]


References
1 Impact of dietary gut microbial metabolites on the epigenome. Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):20170359. doi: 10.1098/rstb.2017.0359.
2 Urolithins, the rescue of "old" metabolites to understand a "new" concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status. Mol Nutr Food Res. 2017 Jan;61(1). doi: 10.1002/mnfr.201500901. Epub 2016 Jun 20.
3 Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-trans retinoic acid-induced superoxide generating activity of U937 cells. Biochem Biophys Rep. 2021 Jan 6;25:100891. doi: 10.1016/j.bbrep.2020.100891. eCollection 2021 Mar.

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