Details of Microbe Species (MIC)

General Information of MIC (ID: MC1151)
  MIC Name
Ruminococcus
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Oscillospiraceae
Genus: Ruminococcus
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Fermentative
  Gram
Positive
  No. of Coding Genes
5759
  No. of Non-Coding Genes
46
  No. of Small Non-Coding Genes
46
  No. of Gene Transcripts
5936
  No. of Pseudogenes 131
  Description
Ruminococcus is a genus of bacteria in the class Clostridia. They are anaerobic, gram-positive gut microbes.
  External Links Taxonomy ID 1263
GutMDisorder ID gm0587
Genome Assembly ID ASM291553v1

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [1], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [3], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [4], [5]
Histone Deacetylation HDAC2 EM Info . . . [6], [2]
Histone Deacetylation HDAC1 EM Info . . . [6], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [7], [2]
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [4], [5]
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [3], [2]


References
1 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
2 Lactobacillus casei Strain Shirota Alleviates Constipation in Adults by Increasing the Pipecolinic Acid Level in the Gut Front Microbiol. 2019 Feb 21;10:324. doi: 10.3389/fmicb.2019.00324. eCollection 2019.
3 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
4 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
5 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
6 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
7 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.

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