Details of Microbe Species (MIC)

General Information of MIC (ID: MC1106)
  MIC Name
Mycobacterium tuberculosis
  Synonym
Bacterium tuberculosis
  Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
  Oxygen Sensitivity
Aerobe
  Microbial Metabolism
Saccharolytic; Respiratory
  Gram
Gram-negative or Gram-positive
  Host Relationship
Pathogen
  No. of Coding Genes
3105
  No. of Non-Coding Genes
47
  No. of Small Non-Coding Genes
47
  No. of Gene Transcripts
3152
  Description
Mycobacteria tuberculosis is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis.
  External Links Taxonomy ID 1773
Genome Assembly ID ASM95067v1
GOLD Database ID Go0006687
GIMICA ID MIC00857


Full List of Protein(s) Produced by This MIC
     Protein Type: Microbial secreted proteins
           Protein Name: ESAT-6 Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
miRNA miR-let-7f EM Info RAW264.7 cells . Mycobacterium tuberculosis infection [1]
           Protein Name: LpqH Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation CIITA EM Info . promoter . [2]
           Protein Name: Rv1988 Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation TRAF3 EM Info . promoter Rv1988 infection [3]
DNA Methylation NOX4 EM Info . promoter Rv1988 infection [3]
DNA Methylation NOX1 EM Info . promoter Rv1988 infection [3]
DNA Methylation NOS2 EM Info . promoter Rv1988 infection [3]
Histone Dimethylation H3 EM Info THP-1 cells arginine 42 Rv1988 infection [4]
           Protein Name: Rv2966c Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation H2AFY2 EM Info THP-1 cells intron Mycobacterium tuberculosis infection [5]
Histone Trimethylation H3 EM Info HEK293 cells lysine 36 . [5]
Histone Trimethylation H3 EM Info HEK293 cells lysine 4 . [5]
           Protein Name: Rv3423.1 Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3 EM Info Macrophages lysine 14 Mycobacterium tuberculosis infection [6]
Histone Acetylation H3 EM Info Macrophages lysine 9 Mycobacterium tuberculosis infection [6]
           Protein Name: Rv3763 Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation Histone H3 EM Info RAW264.7 cells CIITA pIV locus Mycobacterium tuberculosis infection [7]
Histone Acetylation Histone H4 EM Info RAW264.7 cells CIITA pIV locus Mycobacterium tuberculosis infection [7]

References
1 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
2 Histone modifications and chromatin remodeling during bacterial infections. Cell Host Microbe. 2008 Aug 14;4(2):100-9. doi: 10.1016/j.chom.2008.07.009.
3 Learning epigenetic regulation from mycobacteria. Microb Cell. 2016 Jan 18;3(2):92-94. doi: 10.15698/mic2016.02.480.
4 Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3 Nat Commun. 2015 Nov 16;6:8922. doi: 10.1038/ncomms9922.
5 The interaction of mycobacterial protein Rv2966c with host chromatin is mediated through non-CpG methylation and histone H3/H4 binding. Nucleic Acids Res. 2015 Apr 30;43(8):3922-37. doi: 10.1093/nar/gkv261. Epub 2015 Mar 30.
6 Pathogenic mechanisms of intracellular bacteria Curr Opin Infect Dis. 2017 Jun;30(3):309-315. doi: 10.1097/QCO.0000000000000363.
7 Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling. J Immunol. 2006 Apr 1;176(7):4323-30. doi: 10.4049/jimmunol.176.7.4323.

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