Details of Microbe Species (MIC)

General Information of MIC (ID: MC1026)
  MIC Name
Sedimentibacter
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Tissierellia
Order: .
Family: .
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Fermentative
  Gram
Negative
  Host Relationship
Pathogen
  Description
Sedimentibacter is a gram-positive, anaerobic bacteria belongs to the class of Tissierellia.
  External Links Taxonomy ID 190972
Genome Assembly ID Fuso_varium_ATCC_27725_V2

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Valerate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3 EM Info . . . [1], [2]
Histone Acetylation H4 EM Info . . . [1], [2]
Histone Deacetylation HDAC1 EM Info HT-29 cells . . [1], [2]
Histone Deacetylation HDAC2 EM Info HT-29 cells . . [3], [2]
Histone Deacetylation HDAC2 EM Info HT-29 cells . Health [3], [2]
Histone Deacetylation HDAC3 EM Info HT-29 cells . . [3], [2]
     Molecule Type: Polyamines
           Metabolite Name: Spermidine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3 EM Info Dermal fibroblasts MMP-2 . [4], [2]
Histone Deacetylation SIRT1 EM Info Dermal fibroblasts MMP-2 . [1], [2]
Histone Deacetylation HDAC1 EM Info Dermal fibroblasts MMP-2 . [4], [2]
Histone Demethylation LSD1 EM Info . . . [5], [2]


References
1 Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid. PLoS One. 2018 Jul 27;13(7):e0201073. doi: 10.1371/journal.pone.0201073. eCollection 2018.
2 Stages of pregnancy and weaning influence the gut microbiota diversity and function in sows J Appl Microbiol. 2019 Sep;127(3):867-879. doi: 10.1111/jam.14344. Epub 2019 Jul 1.
3 Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs. Int J Biol Macromol. 2012 Dec;51(5):1003-7. doi: 10.1016/j.ijbiomac.2012.08.013. Epub 2012 Aug 25.
4 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.

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