| General Information of MIC (ID: MC1025) |
| MIC Name |
Megasphaera
|
| Lineage |
Kingdom: Bacteria
Phylum: Firmicutes
Class: Negativicutes
Order: Veillonellales
Family: Veillonellaceae
Genus: Megasphaera
|
| Oxygen Sensitivity |
Obligate anaerobe
|
| Microbial Metabolism |
Fermentative
|
| Gram |
Negative
|
| Host Relationship |
Pathogen
|
| Description |
Megasphaera is a gram-negative anaerobic bacteria, part of Clostridia genus. Oxygen is toxic to these bacteria.
|
| External Links |
Taxonomy ID |
906
|
| GutMDisorder ID |
gm0435
|
| Full List of Metabolite(s) Produced by This MIC |
| Molecule Type: Polyamines |
|---|
| Metabolite Name: Spermidine |
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|
| Detailed Infomation |
Meta Info
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|
Metabolic Classification |
Microbial producted compound [end-products] |
| Modification Type |
Molecule |
EM Info |
Cell/Tissue Type |
Modified sites |
Condition |
REF |
| Histone Acetylation |
H3 |
EM Info
|
Dermal fibroblasts |
MMP-2 |
. |
[1], [2] |
| Histone Deacetylation |
HDAC1 |
EM Info
|
Dermal fibroblasts |
MMP-2 |
. |
[1], [2] |
| Histone Deacetylation |
SIRT1 |
EM Info
|
Dermal fibroblasts |
MMP-2 |
. |
[1], [2] |
| Histone Demethylation |
LSD1 |
EM Info
|
. |
. |
. |
[3], [2] |
| References |
| 1 |
Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs. Int J Biol Macromol. 2012 Dec;51(5):1003-7. doi: 10.1016/j.ijbiomac.2012.08.013. Epub 2012 Aug 25.
|
| 2 |
Stages of pregnancy and weaning influence the gut microbiota diversity and function in sows J Appl Microbiol. 2019 Sep;127(3):867-879. doi: 10.1111/jam.14344. Epub 2019 Jul 1.
|
| 3 |
Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
|
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