Details of Microbe Species (MIC)

General Information of MIC (ID: MC0997)
  MIC Name
Succinivibrio
  Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Aeromonadales
Family: Succinivibrionaceae
Genus: Succinivibrio
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Fermentative
  Gram
Negative
  Description
Succinivibrio are anaerobic bacteria that ferment glucose. They obtains nitrogen through ammonia.
  External Links Taxonomy ID 83770
GutMDisorder ID gm0629

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [1], [2]
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [3], [2]
     Molecule Type: Polyamines
           Metabolite Name: Spermidine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3 EM Info Dermal fibroblasts MMP-2 . [4], [2]
Histone Deacetylation SIRT1 EM Info Dermal fibroblasts MMP-2 . [3], [2]
Histone Deacetylation HDAC1 EM Info Dermal fibroblasts MMP-2 . [4], [2]
Histone Demethylation LSD1 EM Info . . . [4], [2]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Stages of pregnancy and weaning influence the gut microbiota diversity and function in sows J Appl Microbiol. 2019 Sep;127(3):867-879. doi: 10.1111/jam.14344. Epub 2019 Jul 1.
3 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
4 Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs. Int J Biol Macromol. 2012 Dec;51(5):1003-7. doi: 10.1016/j.ijbiomac.2012.08.013. Epub 2012 Aug 25.

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