Details of Microbe Species (MIC)

General Information of MIC (ID: MC0956)
  MIC Name
Clostridium perfringens
  Synonym
Bacillus perfringens
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Clostridium
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Positive
  Host Relationship
Pathogen
  Genome Size (bp)
4070811
  No. of Coding Genes
3661
  No. of Non-Coding Genes
133
  No. of Small Non-Coding Genes
133
  No. of Gene Transcripts
3794
  No. of Base Pairs
4070811
  Description
Clostridium perfringens is an anaerobic, gram-positive, spore-forming, rod-shaped pathogenic bacteria of the genus Clostridium.
  External Links Taxonomy ID 1502
GutMDisorder ID gm0206
Genome Assembly ID ASM157978v1
GOLD Database ID Go0000596
GIMICA ID MIC00411

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [1], [2]
     Molecule Type: Phenolic compounds
           Metabolite Name: Phenolic acid Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [3], [4]

Full List of Protein(s) Produced by This MIC
     Protein Type: .
           Protein Name: Perfringolysin Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Dephosphorylation H3 EM Info HeLa cells serine 10 Clostridium perfringens infection [5]

References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 p-Cresyl Sulfate. Toxins (Basel). 2017 Jan 29;9(2):52. doi: 10.3390/toxins9020052.
3 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
4 Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils J Biomed Sci. 2012 Oct 12;19(1):89. doi: 10.1186/1423-0127-19-89.
5 Histone modifications induced by a family of bacterial toxins Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13467-72. doi: 10.1073/pnas.0702729104. Epub 2007 Aug 3.

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