Details of Microbe Species (MIC)

General Information of MIC (ID: MC0947)
  MIC Name
Acholeplasma laidlawii
  Lineage Kingdom: Bacteria
Phylum: Tenericutes
Class: Mollicutes
Order: Acholeplasmatales
Family: Acholeplasmataceae
Genus: Acholeplasma
  Gram
Positive
  Description
Acholeplasma laidlawii are small bacteria which lack a cell wall.
  External Links Taxonomy ID 2148

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Other metabolites
           Metabolite Name: S-Adenosyl Homocysteine (SAH) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Methylation HMT EM Info . . . [1], [2]
Histone Trimethylation H3 EM Info Colorectal cancer cells lysine 4 . [3], [2]
           Metabolite Name: S-Adenosyl Methionine (SAM) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA hypermethylation ASB7 EM Info HT-29 cells Cg20072001 Colorectal carcinoma [4], [5]
DNA hypermethylation MIR636 EM Info HT-29 cells Cg21028463 Colorectal carcinoma [4], [5]
DNA hypermethylation SLC39A6 EM Info HT-29 cells Cg04447424 Colorectal carcinoma [4], [5]
DNA Hypomethylation CRISPLD1 EM Info HT-29 cells Cg15953602 Colorectal carcinoma [4], [2]
DNA Hypomethylation DTX1 EM Info HT-29 cells Cg22685245 Colorectal carcinoma [4], [2]
DNA Hypomethylation HAAO EM Info SW480 cells Cg08421126 Colorectal carcinoma [4], [5]
DNA Hypomethylation TP53INP1 EM Info HT-29 cells Cg13393036 Colorectal carcinoma [4], [5]
DNA Hypomethylation TSPAN11 EM Info HT-29 cells Cg20372004 Colorectal carcinoma [4], [5]
DNA Hypomethylation MYOCD EM Info HT-29 cells Cg20062401 Colorectal carcinoma [4], [5]
DNA Hypomethylation SEZ6L EM Info HT-29 cells Cg09983462 Colorectal carcinoma [4], [5]
DNA Hypomethylation CYP4F22 EM Info HT-29 cells Cg24456663 Colorectal carcinoma [4], [5]
DNA Hypomethylation GATA4 EM Info HT-29 cells Cg14900471 Colorectal carcinoma [4], [5]
DNA Hypomethylation PAK7 EM Info HT-29 cells Cg22457984 Colorectal carcinoma [4], [5]
DNA Hypomethylation SNORA49 EM Info HT-29 cells Cg07588358 Colorectal carcinoma [4], [5]
DNA Hypomethylation TAL1 EM Info SW480 cells Cg11432900 Colorectal carcinoma [4], [5]
DNA Hypomethylation TAL1 EM Info SW480 cells Cg11766986 Colorectal carcinoma [4], [5]
Histone Methylation H3K4 EM Info RAW 264.7 cells TNF-alpha promoter . [6], [2]


References
1 Epigenetics: A New Bridge between Nutrition and Health. Adv Nutr. 2010 Nov;1(1):8-16. doi: 10.3945/an.110.1004. Epub 2010 Nov 16.
2 Metabolomic analysis of three Mollicute species. PLoS One. 2014 Mar 4;9(3):e89312. doi: 10.1371/journal.pone.0089312. eCollection 2014.
3 Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. Cell Metab. 2015 Nov 3;22(5):861-73. doi: 10.1016/j.cmet.2015.08.024. Epub 2015 Sep 24.
4 S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression. Cells. 2020 Aug 9;9(8):1864. doi: 10.3390/cells9081864.
5 Progress in the microbial production of S-adenosyl-L-methionine World J Microbiol Biotechnol. 2016 Sep;32(9):153. doi: 10.1007/s11274-016-2102-8. Epub 2016 Jul 27.
6 S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation. Hepatology. 2008 May;47(5):1655-66. doi: 10.1002/hep.22231.

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