Details of Microbe Species (MIC)

General Information of MIC (ID: MC0946)
  MIC Name
Lactobacillus paracasei
  Synonym
Lactobacillus paracasei
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
  Oxygen Sensitivity
Facultative anaerobe
  Microbial Metabolism
Saccharolytic; Respiratory or Fermentative
  Gram
Positive
  Host Relationship
Probiotic; Commensal
  Genome Size (bp)
2924325
  No. of Coding Genes
2717
  No. of Non-Coding Genes
75
  No. of Small Non-Coding Genes
75
  No. of Gene Transcripts
2792
  No. of Base Pairs
2973347
  Description
Lactobacillus paracasei is a gram-positive, facultatively heterofermentative species of lactic acid bacteria that are commonly used in dairy product fermentation and probiotics. L. paracasei is a bacteria that operates by commensalism. It is commonly found in many human habitats such as human intestinal tracts and mouths. It is has been identified as having probiotic properties.
  External Links Taxonomy ID 1597
GutMDisorder ID gm0393
Genome Assembly ID ASM119156v1
GOLD Database ID Go0003661
GIMICA ID MIC00726

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Other metabolites
           Metabolite Name: S-Adenosyl Homocysteine (SAH) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Methylation HMT EM Info . . . [1], [2]
Histone Trimethylation H3 EM Info Colorectal cancer cells lysine 4 . [3], [2]
     Molecule Type: Polyamines
           Metabolite Name: Spermine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT3B EM Info Jurkat cells . . [4], [2]
DNA Methylation DNMT3A EM Info Jurkat cells . . [4], [2]
Histone Acetylation H3 EM Info HT1080 cells . . [2], [5]
Histone Acetylation HAT1 EM Info HT1080 cells . . [2], [5]
Histone Deacetylation HDAC1 EM Info HT1080 cells . . [2], [5]
Histone Deacetylation SIRT1 EM Info HT1080 cells . . [2], [5]


References
1 Epigenetics: A New Bridge between Nutrition and Health. Adv Nutr. 2010 Nov;1(1):8-16. doi: 10.3945/an.110.1004. Epub 2010 Nov 16.
2 Lactobacillus paracasei metabolism of rice bran reveals metabolome associated with Salmonella Typhimurium growth reduction. J Appl Microbiol. 2017 Jun;122(6):1639-1656. doi: 10.1111/jam.13459. Epub 2017 May 11.
3 Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. Cell Metab. 2015 Nov 3;22(5):861-73. doi: 10.1016/j.cmet.2015.08.024. Epub 2015 Sep 24.
4 Extracellular Spermine Activates DNA Methyltransferase 3A and 3B. Int J Mol Sci. 2019 Mar 12;20(5):1254. doi: 10.3390/ijms20051254.
5 Activation of p53 by spermine mediates induction of autophagy in HT1080 cells. Int J Biol Macromol. 2014 Feb;63:56-63. doi: 10.1016/j.ijbiomac.2013.10.041. Epub 2013 Nov 1.

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