Details of Microbe Species (MIC)

General Information of MIC (ID: MC0883)
  MIC Name
Lactobacillus salivarius
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
  Oxygen Sensitivity
Facultative anaerobe
  Microbial Metabolism
Saccharolytic; Respiratory or Fermentative
  Gram
Positive
  Host Relationship
Probiotic
  Genome Size (bp)
2320461
  No. of Coding Genes
2152
  No. of Non-Coding Genes
96
  No. of Small Non-Coding Genes
96
  No. of Gene Transcripts
2250
  No. of Pseudogenes 2
  No. of Base Pairs
2320461
  Description
Lactobacillus salivarius is a facultative anaerobic, gram-positive bacteria. It is commonly isolated from human, porcine, and avian gastrointestinal tracts. It has proved to be an effective probiotic with at least temporary influence on gut microbiota.
  External Links Taxonomy ID 1624
GutMDisorder ID gm0409
Genome Assembly ID ASM75836v1
GOLD Database ID Go0004608
GIMICA ID MIC00735

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Vitamins
           Metabolite Name: K3 Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Arylation H3 EM Info MCF-7 cells Cys110 Breast cancer [1], [2]
Histone Arylation H3 EM Info SKBr3 cells Cys110 Breast cancer [1], [2]
Histone Arylation H3 EM Info T47D cells Cys110 Breast cancer [1], [2]
Histone Deacetylation HDAC6 EM Info HuH-7 cells . Liver cancer [3], [2]


References
1 Vitamin K3 (menadione)-induced oncosis associated with keratin 8 phosphorylation and histone H3 arylation. Mol Pharmacol. 2005 Sep;68(3):606-15. doi: 10.1124/mol.105.013474. Epub 2005 Jun 6.
2 Effect of pH and dilution rate on specific production rate of extra cellular metabolites by Lactobacillus salivarius UCO_979C in continuous culture Appl Microbiol Biotechnol. 2015 Aug;99(15):6417-29. doi: 10.1007/s00253-015-6526-0. Epub 2015 Mar 25.
3 Vitamin K(3) chloro derivative (VKT-2) inhibits HDAC6, activates autophagy and apoptosis, and inhibits aggresome formation in hepatocellular carcinoma cells. Biochem Pharmacol. 2020 Oct;180:114176. doi: 10.1016/j.bcp.2020.114176. Epub 2020 Jul 25.

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