Details of Microbe Species (MIC)

General Information of MIC (ID: MC0876)
  MIC Name
Campylobacter fetus
  Synonym
Spirillum fetus, Vibrio fetus
  Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Campylobacteraceae
Genus: Campylobacter
  Oxygen Sensitivity
Microaerophile
  Microbial Metabolism
Strictly Respiratory; Asaccharolytic
  Gram
Negative
  Host Relationship
Pathogen
  Description
Campylobacter fetus is a rod-shaped, gram-negative species of bacteria within the genus Campylobacter of phylum Proteobacteria.
  External Links Taxonomy ID 196

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Other metabolites
           Metabolite Name: Hydrogen sulfide (H2S) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation Foxp3 EM Info Treg cells Promoter Adoptive transfer colitis [1], [2]
DNA Methylation AT1b EM Info Inflammatory cells Genbank:U01033 277-1454 Hypertension [3], [2]
DNA Methylation DNMT1 EM Info HUVECs . . [4], [2]
DNA Methylation DNMT3A EM Info Smooth muscle cells . . [5], [2]
DNA Methylation TFAM EM Info Smooth muscle cells promoter: 210 bp and30 bp . [5], [2]
Histone Acetylation H3 EM Info THP-1 cells IL-6 promoter Inflammation [6], [2]
Histone Acetylation H3 EM Info THP-1 cells TNF-Alpha promoter Inflammation [6], [2]
Histone Deacetylation SIRT3 EM Info Cardiomyocytes . Myocardial hypertrophy [7], [2]
Histone Deacetylation HDAC EM Info THP-1 cells . Inflammation [6], [2]
Histone Deacetylation SIRT1 EM Info A549 cells . Mitochondrial dysfunction [8], [2]
Histone Methylation H3K27 EM Info THP-1 cells IL-6 promoter Inflammation [6], [2]
Histone Methylation H3K27 EM Info THP-1 cells TNF-Alpha promoter Inflammation [6], [2]
Histone Methylation H3K9 EM Info THP-1 cells IL-6 promoter Inflammation [6], [2]
Histone Methylation H3K9 EM Info THP-1 cells TNF-Alpha promoter Inflammation [6], [2]
miRNA miR-126-3p EM Info HUVECs . . [4], [2]
miRNA miR-129 EM Info Glomerular endothelial cells . Hypertension [9], [2]
miRNA miR-194 EM Info Glomerular endothelial cells . Genetic diabetic kidney [10], [2]
miRNA miR-455 EM Info BEAS-2B cells . Hypoxic injury [11], [2]


References
1 Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis. Immunity. 2015 Aug 18;43(2):251-63. doi: 10.1016/j.immuni.2015.07.017. Epub 2015 Aug 11.
2 Tannerella forsythia-produced methylglyoxal causes accumulation of advanced glycation endproducts to trigger cytokine secretion in human monocytes Mol Oral Microbiol. 2018 Aug;33(4):292-299. doi: 10.1111/omi.12224. Epub 2018 May 2.
3 Maternal Renovascular Hypertensive Rats Treatment With Hydrogen Sulfide Increased the Methylation of AT1b Gene in Offspring. Am J Hypertens. 2017 Nov 6;30(12):1220-1227. doi: 10.1093/ajh/hpx124.
4 Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p. Am J Physiol Cell Physiol. 2020 May 1;318(5):C857-C869. doi: 10.1152/ajpcell.00406.2019. Epub 2020 Mar 18.
5 Hydrogen Sulfide Maintains Mitochondrial DNA Replication via Demethylation of TFAM. Antioxid Redox Signal. 2015 Sep 1;23(7):630-42. doi: 10.1089/ars.2014.6186. Epub 2015 May 14.
6 Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling. Int J Mol Med. 2015 Jun;35(6):1741-6. doi: 10.3892/ijmm.2015.2176. Epub 2015 Apr 8.
7 Hydrogen sulfide signaling in regulation of cell behaviors. Nitric Oxide. 2020 Oct 1;103:9-19. doi: 10.1016/j.niox.2020.07.002. Epub 2020 Jul 17.
8 Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1. Aging (Albany NY). 2019 Dec 23;11(24):11844-11864. doi: 10.18632/aging.102454. Epub 2019 Dec 23.
9 Hydrogen sulfide alleviates hypertensive kidney dysfunction through an epigenetic mechanism. Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H874-H885. doi: 10.1152/ajpheart.00637.2016. Epub 2017 Feb 17.
10 GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney. Sci Rep. 2017 Sep 7;7(1):10924. doi: 10.1038/s41598-017-11256-3.
11 Involvement of miR-455 in the protective effect of H(2)S against chemical hypoxia-induced injury in BEAS-2B cells. Pathol Res Pract. 2018 Nov;214(11):1804-1810. doi: 10.1016/j.prp.2018.08.008. Epub 2018 Aug 16.

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