Details of Microbe Species (MIC)

General Information of MIC (ID: MC0786)
  MIC Name
Butyrivibrio
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Lachnospiraceae
Genus: Butyrivibrio
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Negative
  No. of Coding Genes
2232
  No. of Non-Coding Genes
45
  No. of Small Non-Coding Genes
45
  No. of Gene Transcripts
2328
  No. of Pseudogenes 51
  Description
Butyrivibrio is a genus of bacteria in Class Clostridia. Bacteria of this genus are common in the gastrointestinal systems of many animals. Genus Butyrivibrio was first described by Bryant and Small as anaerobic, butyric acid-producing, curved rods.
  External Links Taxonomy ID 830
GutMDisorder ID gm0137
Genome Assembly ID ASM344922v1

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [1], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [3], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [4], [5]
Histone Acetylation H3K9 EM Info KGN cells GPR43 . [3], [2]
Histone Deacetylation HDAC2 EM Info . . . [6], [2]
Histone Deacetylation HDAC1 EM Info . . . [6], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [7], [2]
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [8], [9]
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [4], [5]


References
1 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
2 An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis Genome Med. 2016 Apr 21;8(1):43. doi: 10.1186/s13073-016-0299-7.
3 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
4 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
5 Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients with Behcet's disease (210 characters) Clin Rheumatol. 2019 May;38(5):1437-1445. doi: 10.1007/s10067-018-04419-8. Epub 2019 Jan 9.
6 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
7 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
8 The microbiota-gut-brain axis: An emerging role for the epigenome. Exp Biol Med (Maywood). 2020 Jan;245(2):138-145. doi: 10.1177/1535370219891690. Epub 2019 Dec 5.
9 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.

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