Details of Microbe Species (MIC)

General Information of MIC (ID: MC0785)
  MIC Name
Megasphaera elsdenii
  Synonym
Peptostreptococcus elsdenii
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Negativicutes
Order: Veillonellales
Family: Veillonellaceae
Genus: Megasphaera
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative; Utilize hydrogen as energy source
  Gram
Negative
  Host Relationship
Commensal
  Genome Size (bp)
2412274
  No. of Coding Genes
2017
  No. of Non-Coding Genes
92
  No. of Small Non-Coding Genes
92
  No. of Gene Transcripts
2109
  No. of Base Pairs
2412274
  Description
Megasphaera elsdenii is a gram-negative, obligately anaerobic, saccharolytic, fermentative, lactate fermented to propionate, commensal ruminal bacteria.
  External Links Taxonomy ID 907
GutMDisorder ID gm0435
Genome Assembly ID ASM76319v1
GOLD Database ID Go0519010
GIMICA ID MIC00788

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [1], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [1], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [3], [2]
Histone Crotonylation H3K9 EM Info KGN cells GPR43 . [4], [2]
Histone Deacetylation HDAC2 EM Info . . . [5], [2]
Histone Deacetylation HDAC1 EM Info . . . [5], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [6], [2]


References
1 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
2 The gut microbiome of kittens is affected by dietary protein:carbohydrate ratio and associated with blood metabolite and hormone concentrations Br J Nutr. 2013 May;109(9):1637-46. doi: 10.1017/S0007114512003479. Epub 2012 Aug 31.
3 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
4 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
6 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.

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