Details of Microbe Species (MIC)

General Information of MIC (ID: MC0784)
  MIC Name
Pseudobutyrivibrio
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Pseudobutyrivibrio
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Negative
  Genome Size (bp)
2911787
  Description
Pseudobutyrivibrio is a gram-negative, anaerobic and non-spore-forming bacterial genus from the family of Lachnospiraceae.
  External Links Taxonomy ID 46205
GutMDisorder ID gm0547
GOLD Database ID Go0448987
GIMICA ID MIC01050

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [1], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [1], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [3], [2]
Histone Crotonylation H3K9 EM Info KGN cells GPR43 . [4], [2]
Histone Deacetylation HDAC2 EM Info . . . [5], [2]
Histone Deacetylation HDAC1 EM Info . . . [5], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [6], [2]


References
1 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
2 Gut Microbiota as Diagnostic Tools for Mirroring Disease Progression and Circulating Nephrotoxin Levels in Chronic Kidney Disease: Discovery and Validation Study Int J Biol Sci. 2020 Jan 1;16(3):420-434. doi: 10.7150/ijbs.37421. eCollection 2020.
3 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
4 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
6 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.

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