Details of Microbe Species (MIC)

General Information of MIC (ID: MC0751)
  MIC Name
Anaerostipes
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Lachnospiraceae
Genus: Anaerostipes
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Fermentative
  Gram
Positive
  Description
Anaerostipes is a gram-positive and anaerobic bacterial genus from the family of Lachnospiraceae. Anaerostipes occurs in the human gut. Anaerostipes may protect against colon cancer in humans by producing butyric acid.
  External Links Taxonomy ID 207244
GutMDisorder ID gm0052

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [1], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [1], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [3], [2]
Histone Crotonylation H3K9 EM Info KGN cells GPR43 . [4], [2]
Histone Deacetylation HDAC2 EM Info . . . [5], [2]
Histone Deacetylation HDAC1 EM Info . . . [5], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [6], [2]


References
1 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
2 Intestinal microbiota in infants at high risk for allergy: Effects of prebiotics and role in eczema development J Allergy Clin Immunol. 2018 Apr;141(4):1334-1342.e5. doi: 10.1016/j.jaci.2017.05.054. Epub 2017 Sep 1.
3 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
4 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
6 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.

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