Details of Microbe Species (MIC)

General Information of MIC (ID: MC0735)
  MIC Name
Coprococcus eutactus ATCC 27759
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Coprococcus
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Positive
  Host Relationship
Commensal
  Genome Size (bp)
3102087
  No. of Coding Genes
2982
  No. of Non-Coding Genes
65
  No. of Small Non-Coding Genes
65
  No. of Gene Transcripts
3047
  Description
Coprococcus eutactus ATCC 27759 is a gram-positive and obligate anaerobic strain from the genus of Coprococcus.
  External Links Taxonomy ID 411474
Genome Assembly ID ASM15442v1
GOLD Database ID Go0000905

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [1], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [3], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [2], [4]
Histone Acetylation H3K9 EM Info KGN cells GPR43 . [5], [2]
Histone Acetylation H3K9 EM Info KGN cells GPR41 . [3], [2]
Histone Deacetylation HDAC2 EM Info . . . [6], [2]
Histone Deacetylation HDAC1 EM Info . . . [6], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [7], [2]
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [2], [4]
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [5], [2]


References
1 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
3 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
4 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
5 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.
6 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
7 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.

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