Details of Microbe Species (MIC)

General Information of MIC (ID: MC0733)
  MIC Name
Clostridium sp. L2-50
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Clostridium
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Uncharacterized
  Gram
Uncharacterized
  Host Relationship
Uncharacterized
  Genome Size (bp)
3835902
  No. of Coding Genes
2949
  No. of Non-Coding Genes
54
  No. of Small Non-Coding Genes
54
  No. of Gene Transcripts
3003
  Description
Clostridium sp. L2-50 is a gram-uncharacterized and obligate anaerobic strain from the genus of Clostridium.
  External Links Taxonomy ID 411489
Genome Assembly ID ASM15424v1
GOLD Database ID Go0000902

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [1], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [1], [2]
Histone Acetylation H3K9 EM Info KGN cells GPR41 . [3], [2]
Histone Acetylation H3K9 EM Info KGN cells GPR43 . [3], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [4], [2]
Histone Deacetylation HDAC2 EM Info . . . [5], [2]
Histone Deacetylation HDAC1 EM Info . . . [5], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [6], [2]


References
1 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
3 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.
4 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
6 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.

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