Details of Microbe Species (MIC)

General Information of MIC (ID: MC0696)
  MIC Name
Rhodococcus rhodochrous ATCC 21198
  Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Actinomycetales
Family: Nocardiaceae
Genus: Rhodococcus
  Oxygen Sensitivity
Aerobe
  Microbial Metabolism
Saccharolytic
  Gram
Positive
  Genome Size (bp)
6477549
  No. of Coding Genes
6038
  No. of Non-Coding Genes
2
  No. of Small Non-Coding Genes
2
  No. of Gene Transcripts
6040
  Description
Rhodococcus rhodochrous ATCC 21198 is a gram-positive and aerobic strain from the genus of Rhodococcus.
  External Links Taxonomy ID 1429046
Genome Assembly ID Rhodococcus_rhodochrous.strain_ATCC_21198_v1.0
GOLD Database ID Go0075813

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [1], [2]
     Molecule Type: Fatty acids
           Metabolite Name: Lactate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
miRNA miR-141-3P EM Info Oral epithelial cells . Autistic spectrum disorder [1], [2]
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [3], [1]
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [1], [4]
     Molecule Type: Other metabolites
           Metabolite Name: a-Ketoglutarate (a-Kg) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Trimethylation H3K27 EM Info Mesenchymal stromal stem cells Nanog promoter Age-related osteoporosis [5], [1]
Histone Trimethylation H3K27 EM Info Mesenchymal stromal stem cells Bmp2 promoter Age-related osteoporosis [1], [2]
Histone Trimethylation H3K27 EM Info Mesenchymal stromal stem cells Bmp4 promoter Age-related osteoporosis [1], [2]
Histone Trimethylation H3K9 EM Info Mesenchymal stromal stem cells Bmp2 promoter Age-related osteoporosis [1], [2]
Histone Trimethylation H3K9 EM Info Mesenchymal stromal stem cells Nanog promoter Age-related osteoporosis [1], [4]


References
1 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
2 Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations. Nat Commun. 2020 Nov 5;11(1):5596. doi: 10.1038/s41467-020-19360-1.
3 Potential Associations Among Alteration of Salivary miRNAs, Saliva Microbiome Structure, and Cognitive Impairments in Autistic Children. Int J Mol Sci. 2020 Aug 27;21(17):6203. doi: 10.3390/ijms21176203.
4 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.

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