Details of Microbe Species (MIC)

General Information of MIC (ID: MC0577)
  MIC Name
Pseudomonas fluorescens PfO-1
  Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Pseudomonadaceae
Genus: Pseudomonas
  Oxygen Sensitivity
Aerobe
  Microbial Metabolism
Respiratory
  Gram
Negative
  No. of Coding Genes
5722
  No. of Non-Coding Genes
93
  No. of Small Non-Coding Genes
93
  No. of Gene Transcripts
5816
  No. of Pseudogenes 1
  Description
Pseudomonas fluorescens PfO-1 is a strain of aerobic, gram-negative bacteria.
  External Links Taxonomy ID 205922
Genome Assembly ID ASM1244v1

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Tryptophan Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation ARL4C EM Info Hepatocellular CpG site: Cg15016771 non-alcoholic steatohepatitis [1], [2]
DNA Methylation BMP2 EM Info Hepatocellular CpG site: Cg16831623 non-alcoholic steatohepatitis [1], [2]
DNA Methylation TRPV6 EM Info Hepatocellular CpG site: Cg0642946 non-alcoholic steatohepatitis [3], [2]
DNA Methylation MCC EM Info Hepatocellular CpG site: Cg24094897 non-alcoholic steatohepatitis [2], [4]
DNA Methylation SEMA3E EM Info Hepatocellular CpG site: Cg14519356 non-alcoholic steatohepatitis [2], [4]
DNA Methylation SLCO3A1 EM Info Hepatocellular CpG site: Cg03756778 non-alcoholic steatohepatitis [2], [4]
DNA Methylation SLC22A20 EM Info Hepatocellular CpG site: Cg27428304 non-alcoholic steatohepatitis [2], [4]
DNA Methylation LGALS9 EM Info Hepatocellular CpG site: Cg27625456 non-alcoholic steatohepatitis [2], [4]
DNA Methylation ZNF611 EM Info Hepatocellular CpG site: Cg27182293 non-alcoholic steatohepatitis [2], [5]
DNA Methylation FMNL2 EM Info Hepatocellular CpG site: Cg01467882 non-alcoholic steatohepatitis [6], [2]
DNA Methylation HDAC9 EM Info Hepatocellular CpG site: Cg16925459 non-alcoholic steatohepatitis [6], [2]
DNA Methylation FAM188B EM Info Hepatocellular CpG site: Cg02543636 non-alcoholic steatohepatitis [6], [2]
DNA Methylation CRTAC1 EM Info Hepatocellular CpG site: Cg03888360 non-alcoholic steatohepatitis [6], [2]
DNA Methylation COL4A1 EM Info Hepatocellular CpG site: Cg26090406 non-alcoholic steatohepatitis [6], [2]
DNA Methylation FGD6 EM Info Hepatocellular CpG site: Cg21182715 non-alcoholic steatohepatitis [6], [2]
DNA Methylation ITGB4 EM Info Hepatocellular CpG site: Cg16916914 non-alcoholic steatohepatitis [6], [2]
DNA Methylation GRHL3 EM Info Hepatocellular CpG site: Cg02984188 non-alcoholic steatohepatitis [6], [2]
DNA Methylation FAM100A EM Info Hepatocellular CpG site: Cg05009047 non-alcoholic steatohepatitis [6], [2]
DNA Methylation CLPTM1L EM Info Hepatocellular CpG site: Cg10641823 non-alcoholic steatohepatitis [6], [2]
DNA Methylation CLDN8 EM Info Hepatocellular CpG site: Cg06427867 non-alcoholic steatohepatitis [6], [2]
DNA Methylation C1QTNF1 EM Info Hepatocellular CpG site: Cg00193613 non-alcoholic steatohepatitis [6], [2]
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [7], [2]
Histone Acetylation H3K27 EM Info HepG2 cells ACACA promoter Hypoxia [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells VEGF promoter Hypoxia [1], [2]
Histone Acetylation H3K56 EM Info HepG2 cells ACACA promoter Hypoxia [1], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [1], [2]
Histone Acetylation H3K56 EM Info HepG2 cells LDHA promoter Hypoxia [1], [2]
Histone Acetylation H3K56 EM Info HepG2 cells VEGF promoter Hypoxia [1], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [1], [2]
Histone Acetylation H3K9 EM Info HepG2 cells FASN promoter Hypoxia [1], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [1], [2]
Histone Acetylation H3K9 EM Info HepG2 cells VEGF promoter Hypoxia [1], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [2], [5]
           Metabolite Name: Lactate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
miRNA miR-141-3P EM Info Oral epithelial cells . Autistic spectrum disorder [1], [2]
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [1], [2]
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [1], [2]
     Molecule Type: Other metabolites
           Metabolite Name: a-Ketoglutarate (a-Kg) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Trimethylation H3K27 EM Info Mesenchymal stromal stem cells Bmp2 promoter Age-related osteoporosis [1], [2]
Histone Trimethylation H3K27 EM Info Mesenchymal stromal stem cells Bmp4 promoter Age-related osteoporosis [1], [2]
Histone Trimethylation H3K27 EM Info Mesenchymal stromal stem cells Nanog promoter Age-related osteoporosis [1], [2]
Histone Trimethylation H3K9 EM Info Mesenchymal stromal stem cells Bmp2 promoter Age-related osteoporosis [1], [2]
Histone Trimethylation H3K9 EM Info Mesenchymal stromal stem cells Nanog promoter Age-related osteoporosis [1], [2]


References
1 Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids. Liver Int. 2021 Apr;41(4):754-763. doi: 10.1111/liv.14743. Epub 2020 Dec 5.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
3 Potential Associations Among Alteration of Salivary miRNAs, Saliva Microbiome Structure, and Cognitive Impairments in Autistic Children. Int J Mol Sci. 2020 Aug 27;21(17):6203. doi: 10.3390/ijms21176203.
4 Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations. Nat Commun. 2020 Nov 5;11(1):5596. doi: 10.1038/s41467-020-19360-1.
5 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
6 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
7 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.

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