Details of Microbe Species (MIC)

General Information of MIC (ID: MC0356)
  MIC Name
Desulfovibrio piger ATCC 29098
  Synonym
Desulfovibrio piger DSM 749
  Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Deltaproteobacteria
Order: Desulfovibrionales
Family: Desulfovibrionaceae
Genus: Desulfovibrio
  Oxygen Sensitivity
Nanaerobe
  Microbial Metabolism
Only anaerobic respiration with sulfate as electron acceptor; Nonfermentative; asaccharolytic
  Gram
Negative
  Host Relationship
Commensal
  Genome Size (bp)
2826240
  No. of Coding Genes
3114
  No. of Non-Coding Genes
71
  No. of Small Non-Coding Genes
71
  No. of Gene Transcripts
3185
  Description
Desulfovibrio piger ATCC 29098 is a strain of nanaerobic, gram-negative, only anaerobic respiration with sulfate as electron acceptor, non fermentative, asaccharolytic metabolism bacteria.
  External Links Taxonomy ID 411464
Genome Assembly ID ASM15637v1
GOLD Database ID Go0000920

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K9 EM Info HepG2 cells FASN promoter Hypoxia [1], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [3], [2]
Histone Acetylation H3K27 EM Info HepG2 cells VEGF promoter Hypoxia [4], [2]
Histone Acetylation H3K56 EM Info HepG2 cells VEGF promoter Hypoxia [5], [2]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [6], [2]
Histone Acetylation H3K27 EM Info HepG2 cells ACACA promoter Hypoxia [7], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [7], [2]
Histone Acetylation H3K56 EM Info HepG2 cells ACACA promoter Hypoxia [7], [2]
Histone Acetylation H3K56 EM Info HepG2 cells LDHA promoter Hypoxia [7], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [7], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [7], [2]
Histone Acetylation H3K9 EM Info HepG2 cells VEGF promoter Hypoxia [7], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [8], [2]
           Metabolite Name: Lactate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
miRNA miR-141-3P EM Info Oral epithelial cells . Autistic spectrum disorder [9], [2]
     Molecule Type: Other metabolites
           Metabolite Name: Hydrogen sulfide (H2S) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation Foxp3 EM Info Treg cells Promoter Adoptive transfer colitis [10], [2]
DNA Methylation TFAM EM Info Smooth muscle cells promoter: 210 bp and30 bp . [11], [2]
DNA Methylation AT1b EM Info Inflammatory cells Genbank:U01033 277-1454 Hypertension [12], [2]
DNA Methylation DNMT1 EM Info HUVECs . . [13], [2]
DNA Methylation DNMT3A EM Info Smooth muscle cells . . [14], [2]
Histone Acetylation H3 EM Info THP-1 cells TNF-Alpha promoter Inflammation [10], [2]
Histone Acetylation H3 EM Info THP-1 cells IL-6 promoter Inflammation [14], [2]
Histone Deacetylation HDAC EM Info THP-1 cells . Inflammation [10], [2]
Histone Deacetylation SIRT1 EM Info A549 cells . Mitochondrial dysfunction [7], [2]
Histone Deacetylation SIRT3 EM Info Cardiomyocytes . Myocardial hypertrophy [7], [2]
Histone Methylation H3K27 EM Info THP-1 cells IL-6 promoter Inflammation [10], [2]
Histone Methylation H3K27 EM Info THP-1 cells TNF-Alpha promoter Inflammation [10], [2]
Histone Methylation H3K9 EM Info THP-1 cells IL-6 promoter Inflammation [10], [2]
Histone Methylation H3K9 EM Info THP-1 cells TNF-Alpha promoter Inflammation [10], [2]
miRNA miR-126-3p EM Info HUVECs . . [13], [2]
miRNA miR-455 EM Info BEAS-2B cells . Hypoxic injury [7], [2]
miRNA miR-194 EM Info Glomerular endothelial cells . Genetic diabetic kidney [7], [2]
miRNA miR-129 EM Info Glomerular endothelial cells . Hypertension [7], [2]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
3 Hydrogen sulfide signaling in regulation of cell behaviors. Nitric Oxide. 2020 Oct 1;103:9-19. doi: 10.1016/j.niox.2020.07.002. Epub 2020 Jul 17.
4 Hydrogen sulfide alleviates hypertensive kidney dysfunction through an epigenetic mechanism. Am J Physiol Heart Circ Physiol. 2017 May 1;312(5):H874-H885. doi: 10.1152/ajpheart.00637.2016. Epub 2017 Feb 17.
5 GYY4137, a Hydrogen Sulfide Donor Modulates miR194-Dependent Collagen Realignment in Diabetic Kidney. Sci Rep. 2017 Sep 7;7(1):10924. doi: 10.1038/s41598-017-11256-3.
6 Involvement of miR-455 in the protective effect of H(2)S against chemical hypoxia-induced injury in BEAS-2B cells. Pathol Res Pract. 2018 Nov;214(11):1804-1810. doi: 10.1016/j.prp.2018.08.008. Epub 2018 Aug 16.
7 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
8 Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1. Aging (Albany NY). 2019 Dec 23;11(24):11844-11864. doi: 10.18632/aging.102454. Epub 2019 Dec 23.
9 Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis. Immunity. 2015 Aug 18;43(2):251-63. doi: 10.1016/j.immuni.2015.07.017. Epub 2015 Aug 11.
10 Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling. Int J Mol Med. 2015 Jun;35(6):1741-6. doi: 10.3892/ijmm.2015.2176. Epub 2015 Apr 8.
11 Potential Associations Among Alteration of Salivary miRNAs, Saliva Microbiome Structure, and Cognitive Impairments in Autistic Children. Int J Mol Sci. 2020 Aug 27;21(17):6203. doi: 10.3390/ijms21176203.
12 Maternal Renovascular Hypertensive Rats Treatment With Hydrogen Sulfide Increased the Methylation of AT1b Gene in Offspring. Am J Hypertens. 2017 Nov 6;30(12):1220-1227. doi: 10.1093/ajh/hpx124.
13 Hydrogen sulfide rescues high glucose-induced migration dysfunction in HUVECs by upregulating miR-126-3p. Am J Physiol Cell Physiol. 2020 May 1;318(5):C857-C869. doi: 10.1152/ajpcell.00406.2019. Epub 2020 Mar 18.
14 Hydrogen Sulfide Maintains Mitochondrial DNA Replication via Demethylation of TFAM. Antioxid Redox Signal. 2015 Sep 1;23(7):630-42. doi: 10.1089/ars.2014.6186. Epub 2015 May 14.

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