Details of Microbe Species (MIC)

General Information of MIC (ID: MC0294)
  MIC Name
Clostridium bartlettii DSM 16795
  Synonym
Clostridium bartlettii DSM 16795
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Peptostreptococcaceae
Genus: Intestinibacter
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Fermentative
  Gram
Positive
  Host Relationship
Commensal
  Genome Size (bp)
2971856
  Description
Clostridium bartlettii DSM 16795 is a strain of obligate anaerobic, gram-positive bacteria.
  External Links Taxonomy ID 445973

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Methionine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Hypermethylation DNMT3A EM Info Blood cells . . [1], [2]
Histone Trimethylation H3 EM Info Blood cells lysine 4 . [1], [2]
miRNA miR-328-3p EM Info . . . [1], [2]
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [3], [2]
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K27 EM Info HepG2 cells VEGF promoter Hypoxia [4], [2]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [5], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [2], [6]
Histone Acetylation H3K9 EM Info HepG2 cells FASN promoter Hypoxia [2], [6]
Histone Acetylation H3K27 EM Info HepG2 cells ACACA promoter Hypoxia [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [1], [2]
Histone Acetylation H3K56 EM Info HepG2 cells ACACA promoter Hypoxia [1], [2]
Histone Acetylation H3K56 EM Info HepG2 cells LDHA promoter Hypoxia [1], [2]
Histone Acetylation H3K56 EM Info HepG2 cells VEGF promoter Hypoxia [1], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [1], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [1], [2]
Histone Acetylation H3K9 EM Info HepG2 cells VEGF promoter Hypoxia [1], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [7], [2]
           Metabolite Name: Lactate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
miRNA miR-141-3P EM Info Oral epithelial cells . Autistic spectrum disorder [1], [2]


References
1 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
3 Potential Associations Among Alteration of Salivary miRNAs, Saliva Microbiome Structure, and Cognitive Impairments in Autistic Children. Int J Mol Sci. 2020 Aug 27;21(17):6203. doi: 10.3390/ijms21176203.
4 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
5 Hydrogen sulfide signaling in regulation of cell behaviors. Nitric Oxide. 2020 Oct 1;103:9-19. doi: 10.1016/j.niox.2020.07.002. Epub 2020 Jul 17.
6 Dysregulation of methionine metabolism in multiple sclerosis. Neurochem Int. 2018 Jan;112:1-4. doi: 10.1016/j.neuint.2017.10.011. Epub 2017 Oct 26.
7 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.

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