Details of Microbe Species (MIC)

General Information of MIC (ID: MC0124)
  MIC Name
Acidaminococcus sp. D21
  Synonym
Acidaminococcus sp. ADV 255.99,Acidaminococcus sp. D21
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Negativicutes
Order: Selenomonadales
Family: Acidaminococcaceae
Genus: Acidaminococcus
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Asaccharolytic; Glutamate is fermented
  Gram
Negative
  Host Relationship
Commensal
  Genome Size (bp)
2238973
  Description
Acidaminococcus intestini is a species of obligate anaerobic and gram-negative, asaccharolytic bacteria.
  External Links Taxonomy ID 187327

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells VEGF promoter Hypoxia [3], [2]
Histone Acetylation H3K9 EM Info HepG2 cells FASN promoter Hypoxia [4], [2]
Histone Acetylation H3K27 EM Info HepG2 cells ACACA promoter Hypoxia [5], [2]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [5], [2]
Histone Acetylation H3K56 EM Info HepG2 cells ACACA promoter Hypoxia [5], [2]
Histone Acetylation H3K56 EM Info HepG2 cells LDHA promoter Hypoxia [5], [2]
Histone Acetylation H3K56 EM Info HepG2 cells VEGF promoter Hypoxia [5], [2]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [5], [2]
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [5], [2]
Histone Acetylation H3K9 EM Info HepG2 cells VEGF promoter Hypoxia [5], [2]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [6], [2]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [1], [2]
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [7], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [7], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [5], [2]
Histone Acetylation H3K9 EM Info KGN cells GPR41 . [8], [2]
Histone Acetylation H3K9 EM Info KGN cells GPR43 . [8], [2]
Histone Deacetylation HDAC2 EM Info . . . [5], [2]
Histone Deacetylation HDAC1 EM Info . . . [5], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [5], [2]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
3 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
4 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
5 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
6 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
7 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
8 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.

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