Details of Microbe Species (MIC)

General Information of MIC (ID: MC0002)
  MIC Name
Collinsella aerofaciens
  Synonym
Bacteroides aerofaciens, Eubacterium aerofaciens, Pseudobacterium aerofaciens
  Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Coriobacteriia
Order: Coriobacteriales
Family: Coriobacteriaceae
Genus: Collinsella
  Oxygen Sensitivity
Facultative anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Negative
  Description
Collinsella aerofaciens is a species of gram-negative, anaerobic bacteria from the genus Collinsella.
  External Links Taxonomy ID 74426
GutMDisorder ID gm0217

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [1], [2]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [1], [2]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [3], [2]
Histone Crotonylation H3K9 EM Info KGN cells GPR43 . [4], [2]
Histone Deacetylation HDAC2 EM Info . . . [5], [2]
Histone Deacetylation HDAC1 EM Info . . . [5], [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [6], [2]


References
1 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
2 Characterization a Novel Butyric Acid-Producing Bacterium Collinsella aerofaciens Subsp. Shenzhenensis Subsp. Nov Microorganisms. 2019 Mar 13;7(3):78. doi: 10.3390/microorganisms7030078.
3 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
4 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
6 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.

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