General Information of Metabolite (ID: MT089)
  Meta Name
Bleomycin
  Unify Name
Bleomycin
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
Bleocin;Bleomicin;Bleomycin a2;Bleomycin sulfate;Bleomycin sulphate;BLM;Almirall brand OF bleomycin sulfate;Bleo cell;Bleo-cell;BLEOcell;Bellon brand OF bleomycin sulfate;Bellon, bleomycine;Blanoxan;Blenoxane;Bleolem;Bleomicina;Bleomycin a(2);Bleomycin b(2);Bleomycin b2;Bleomycins;Bleomycinum mack;Bleomycine bellon;Bristol myers squibb brand OF bleomycin sulfate;Bristol-myers squibb brand OF bleomycin sulfate;Bull brand OF bleomycin sulfate;Lemery brand OF bleomycin sulfate;Lundbeck brand OF bleomycin sulfate;Mack brand OF bleomycin sulfate;Mack, bleomycinum;Sulfate, bleomycin;Cell pharm brand OF bleomycin sulfate;Bleomycin
  Molecule Type
Other metabolites
  Formula
C55H84N17O21S3
  Inchi Key
OYVAGSVQBOHSSS-WXFSZRTFSA-O
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Bleomycin, also known as bleomycin sulfate or BLM, belongs to the class of organic compounds known as hybrid glycopeptides. Hybrid glycopeptides are compounds containing a carbohydrate component linked to a hybrid peptide component. Thus, bleomycin is considered to be a non-ribosomal peptide/polyketide hybrid lipid molecule. Bleomycin is a drug which is used for palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas. Bleomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. Bleomycin is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Bleomycin is formally rated as a possible carcinogen (by IARC 2B) and is also a potentially toxic compound. Bleomycin A2 is used as the representative structure for Bleomycin. Bleomycin may cause irritation to eyes, skin and respiratory tract.
  External Links   HMDB ID   HMDB0014435
  KEGG ID   C06854

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC2 EM Info A549 cells . Pulmonary fibrosis [1], [2]
Histone Deacetylation HDAC6 EM Info A549 cells . Pulmonary fibrosis [1], [2]

The microbes that produce this metabolite
      Streptomyces
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Streptomyces is the largest genus of Actinobacteria and the type genus of the family Streptomycetaceae. Genus of nonmotile, aerobic, gram-positive bacteria that grows as a many-branched mycelium.

References
1 Histone Deacetylases Promote ER Stress Induced Epithelial Mesenchymal Transition in Human Lung Epithelial Cells. Cell Physiol Biochem. 2018;46(5):1821-1834. doi: 10.1159/000489367. Epub 2018 Apr 25.
2 Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking Curr Top Med Chem. 2016;16(15):1705-16. doi: 10.2174/1568026616666151012111046.

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