Synonym |
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Bleocin;Bleomicin;Bleomycin a2;Bleomycin sulfate;Bleomycin sulphate;BLM;Almirall brand OF bleomycin sulfate;Bleo cell;Bleo-cell;BLEOcell;Bellon brand OF bleomycin sulfate;Bellon, bleomycine;Blanoxan;Blenoxane;Bleolem;Bleomicina;Bleomycin a(2);Bleomycin b(2);Bleomycin b2;Bleomycins;Bleomycinum mack;Bleomycine bellon;Bristol myers squibb brand OF bleomycin sulfate;Bristol-myers squibb brand OF bleomycin sulfate;Bull brand OF bleomycin sulfate;Lemery brand OF bleomycin sulfate;Lundbeck brand OF bleomycin sulfate;Mack brand OF bleomycin sulfate;Mack, bleomycinum;Sulfate, bleomycin;Cell pharm brand OF bleomycin sulfate;Bleomycin
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Description |
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Bleomycin, also known as bleomycin sulfate or BLM, belongs to the class of organic compounds known as hybrid glycopeptides. Hybrid glycopeptides are compounds containing a carbohydrate component linked to a hybrid peptide component. Thus, bleomycin is considered to be a non-ribosomal peptide/polyketide hybrid lipid molecule. Bleomycin is a drug which is used for palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas. Bleomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. Bleomycin is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. Bleomycin is formally rated as a possible carcinogen (by IARC 2B) and is also a potentially toxic compound. Bleomycin A2 is used as the representative structure for Bleomycin. Bleomycin may cause irritation to eyes, skin and respiratory tract.
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