General Information of EM (ID: EM00057)
  Official Symbol
HDAC2
  Official Full Name
histone deacetylase 2
  Synonym
KDAC2;RPD3;YAF1
  Molecule Type
Protein coding
  Position On Chromosome
chr6(Start:113933028 - End:114011308)
  Strand
-
  Uniprot Entry
Q92769 
  ENSG ID
ENSG00000196591 
  Dnmivd Disease
LUSC 
    Disease Relevance (Click to Show/Hide)
         1B10: Tuberculosis of the respiratory system Tuberculosis (TB) [Tuberculosis of the respiratory system]
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         1F84: Opisthorchiasis Opisthorchis viverrini [Opisthorchiasis]
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         2A00: Primary neoplasms of brain Glioma [Primary neoplasms of brain]
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         2A00: Primary neoplasms of brain Oligodendroglial tumors [Primary neoplasms of brain]
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         2A01: Primary neoplasms of meninges Meningioma [Primary neoplasms of meninges]
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         2A90: Mature T-cell lymphoma, specified types, nodal or systemic Anaplastic large cell lymphoma (ALCL) [Mature T-cell lymphoma, specified types, nodal or systemic]
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         2B6B: Malignant neoplasms of nasopharynx Nasopharyngeal carcinoma (NPC) [Malignant neoplasms of nasopharynx]
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         2B70: Malignant neoplasms of oesophagus Barrett's esophagus and esophageal adenocarcinoma [Malignant neoplasms of oesophagus]
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         2B70: Malignant neoplasms of oesophagus Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus]
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         2B72: Malignant neoplasms of stomach Gastric cancer [Malignant neoplasms of stomach]
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         2B80: Malignant neoplasms of small intestine Small intestinal neuroendocrine tumours (SINETs) [Malignant neoplasms of small intestine]
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         2B90: Malignant neoplasms of colon Colon adenocarcinoma [Malignant neoplasms of colon]
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         2B90: Malignant neoplasms of colon Colorectal cancer [Malignant neoplasms of colon]
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         2C10: Malignant neoplasm of pancreas Pancreatic ductal adenocarcinoma (PDAC) [Malignant neoplasm of pancreas]
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         2C25: Malignant neoplasms of bronchus or lung Lung adenocarcinoma [Malignant neoplasms of bronchus or lung]
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         2C25: Malignant neoplasms of bronchus or lung Lung cancer [Malignant neoplasms of bronchus or lung]
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         2C25: Malignant neoplasms of bronchus or lung Non small cell lung cancer (NSCLC) [Malignant neoplasms of bronchus or lung]
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         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
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         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
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         2C82: Malignant neoplasms of prostate Prostate cancer [Malignant neoplasms of prostate]
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         2D10: Malignant neoplasms of thyroid gland Thyroid tumors [Malignant neoplasms of thyroid gland]
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         4A20: Acquired immunodeficiencies Immunodeficiency [Acquired immunodeficiencies]
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         4A40: Lupus erythematosus Systemic lupus erythematosus (SLE) [Lupus erythematosus]
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         4A43: Overlap or undifferentiated nonorgan specific systemic autoimmune disease Sjgren's Syndrome [Overlap or undifferentiated nonorgan specific systemic autoimmune disease]
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         4A84: Anaphylaxis Allergy [Anaphylaxis]
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         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
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         5B81: Obesity Obesity [Obesity]
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         6A00: Disorders of intellectual development Intellectual disability and congenital anomalies(ID/CA) [Disorders of intellectual development]
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         6A02: Autism spectrum disorder Autism [Autism spectrum disorder]
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         6A20: Schizophrenia Schizophrenia [Schizophrenia]
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         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
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         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
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         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
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         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
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         8A40: Multiple sclerosis Multiple sclerosis [Multiple sclerosis]
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         9A01: Infectious disorders of eyelid Human eye and its diseases [Infectious disorders of eyelid]
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         BD40: Atherosclerotic chronic arterial occlusive disease Atherosclerosis [Atherosclerotic chronic arterial occlusive disease]
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         CA22: Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) [Chronic obstructive pulmonary disease]
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         CA23: Asthma Allergic asthma [Asthma]
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         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
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         DA0C: Periodontal disease Periodontitis [Periodontal disease]
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         DB92: Non-alcoholic fatty liver disease Nonalcoholic fatty liver disease (NAFLD) [Non-alcoholic fatty liver disease]
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         DD70: Crohn disease Crohn's disease [Crohn disease]
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         EE60: Keloid or hypertrophic scars Keloid [Keloid or hypertrophic scars]
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         FA0Z: Osteoarthritis Osteoarthritis (OA) [Osteoarthritis]
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         FA20: Rheumatoid arthritis Rheumatoid arthritis [Rheumatoid arthritis]
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         FA21: Psoriatic arthritis Psoriatic [Psoriatic arthritis]
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         GA10: Endometriosis Endometriosis [Endometriosis]
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         JA24: Pre-eclampsia Preeclampsia (PE) [Pre-eclampsia]
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         LA02: Spina bifida Neural tube defects (NTDs) [Spina bifida]
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         LA4Z: Clefts of lip, alveolus or palate Non-syndromic cleft lip and palate [Clefts of lip, alveolus or palate]
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         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
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         LD2F: Syndromes with multiple structural anomalies, without predominant body system involvement Silver russell syndrome [Syndromes with multiple structural anomalies, without predominant body system involvement]
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         LD40: Complete trisomies of the autosomes Down syndrome (DS) [Complete trisomies of the autosomes]
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         LD44: Deletions of the autosomes Deletion or duplication of chromosome 7q11.23 [Deletions of the autosomes]
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         MG30: Chronic pain Fibromyalgia [Chronic pain]
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         SD86: Dementia disorder Dementia [Dementia disorder]
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         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XB8M: Congenital Melanoma [Congenital]
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         XH0945: Squamous cell carcinoma Head and neck squamous cell cancer (HNSCC) [Squamous cell carcinoma]
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         XH1E13: Germinoma Germinoma [Germinoma]
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         XH1ND9: Papillary carcinoma of thyroid Papillary thyroid carcinoma [Papillary carcinoma of thyroid]
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         XH1XF3: Osteosarcoma Osteosarcoma [Osteosarcoma]
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         XH3DV3: Adenoma Adenoma [Adenoma]
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         XH4546: Signet ring cell carcinoma Signet ring cell colorectal cancer [Signet ring cell carcinoma]
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         XH46F1: Clear cell renal cell carcinoma Clear cell renal cell carcinoma (ccRCC) [Clear cell renal cell carcinoma]
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         XH4KH2: Adrenal cortical carcinoma Adrenal cortical cancer [Adrenal cortical carcinoma]
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         XH4S92: Leukaemia Leukemia [Leukaemia]
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         XH4W48: Hepatocellular carcinoma Hepatocellular carcinoma (HCC) [Hepatocellular carcinoma]
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         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
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         XH6PH6: Astrocytoma Astrocytoma [Astrocytoma]
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         XH74S1: Adenocarcinoma Small bowel adenocarcinoma [Adenocarcinoma]
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         XH7F82: Glioblastoma Glioblastoma [Glioblastoma]
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         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia]
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         XH7ZQ4: Atypical teratoid/rhabdoid tumour Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour]
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         XH85Z0: Neuroblastoma Neuroblastoma [Neuroblastoma]
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         XH8AA5: Acute myeloid leukaemia Acute myeloid leukemia (AML) [Acute myeloid leukaemia]
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         XH8D74: Carcinomatosis Cancer [Carcinomatosis]
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         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
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         XH8P29: Medulloblastoma Primary medulloblastoma [Medulloblastoma]
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         XH8SH6: CNS embryonal tumour Primitive neuroectodermal tumors [CNS embryonal tumour]
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         XH94U0: Pituitary adenoma Nonfunctioning pituitary adenomas [Pituitary adenoma]
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         XH98Z3: Schwannoma Schwannoma [Schwannoma]
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         XH9HQ1: Gastrointestinal stromal tumour Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour]
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         XN487: Human immunodeficiency virus Human immunodeficiency virus (HIV) [Human immunodeficiency virus]
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         ZERO(Not Found): Acute mania and inflammatory Acute mania and inflammatory [Acute mania and inflammatory]
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         ZERO(Not Found): Autoimmune arthritis Autoimmune arthritis [Autoimmune arthritis]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Butyrate has been shown to inhibit histone deacetylase 2 (HDAC2).
  Metabolite Name: Butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Butyrate has been shown to inhibit histone deacetylase.
  Metabolite Name: Bleomycin
     Detailed Information Meta Info click to show the detail information of this Metabolite [4], [5]
     Description
Bleomycin has been shown to promote the expression of histone deacetylase 2.
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [6]
     Description
Lipopolysaccharide (LPS) could significantly up-regulated the expression of Histone deacetylase HDAC2.
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [7], [8]
     Description
Valerate has been shown to inhibit histone deacetylase 2 (HDAC2).
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [7], [8]
     Description
Valerate has been shown to inhibite HDAC2 at all concentrations tested.

Protein(s) with this epigenetic modification
  Protein Name: DNA cytosine methyltransferase
     Detailed Information Pro Info click to show the detail information of this protein [9]
     Description
DNA cytosine methyltransferase(MTases) could be associated with the decrease GATC-specific methylation in important cancer-specific genes, such as HDAC2.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
3 Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells. Clin Cancer Res. 2004 Feb 1;10(3):1150-9. doi: 10.1158/1078-0432.ccr-0747-3.
4 Histone Deacetylases Promote ER Stress Induced Epithelial Mesenchymal Transition in Human Lung Epithelial Cells. Cell Physiol Biochem. 2018;46(5):1821-1834. doi: 10.1159/000489367. Epub 2018 Apr 25.
5 Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking Curr Top Med Chem. 2016;16(15):1705-16. doi: 10.2174/1568026616666151012111046.
6 Short-chain fatty acids from periodontal pathogens suppress histone deacetylases, EZH2, and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication. J Virol. 2014 Apr;88(8):4466-79. doi: 10.1128/JVI.03326-13. Epub 2014 Feb 5.
7 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
8 Commensal-derived metabolites govern Vibrio cholerae pathogenesis in host intestine Microbiome. 2019 Sep 14;7(1):132. doi: 10.1186/s40168-019-0746-y.
9 Mycoplasma CG- and GATC-specific DNA methyltransferases selectively and efficiently methylate the host genome and alter the epigenetic landscape in human cells Epigenetics. 2015;10(4):303-18. doi: 10.1080/15592294.2015.1020000. Epub 2015 Feb 19.

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