Target Information

Target General Infomation
Target ID
T95947
Former ID
TTDR01257
Target Name
Acid-sensing ion channel ASIC3
Gene Name
ASIC3
Synonyms
ACCN3; Acid-sensing ion channel 3; Amiloride-sensitive cation channel 3; Neuronal amiloride-sensitive cation channel 3; SLNAC1; TNAC1; Testis sodium channel 1; hASIC3; hTNaC1; ASIC3
Target Type
Research
Disease Fibromyalgia [ICD9: 729.1; ICD10: M79.7]
Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89]
Function
Cation channel with high affinity for sodium, whichis gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.
BioChemical Class
Amiloride-sensitive sodium channel
UniProt ID
Q9UHC3
Sequence
MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQV
AERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA
EHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIF
TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQ
IHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLG
SPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR
KDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY
ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQR
HSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL
Blocker (channel blocker) A-317567 Drug Info [543915]
benzamil Drug Info [543913]
Activator agmatine Drug Info [543915]
arcaine Drug Info [543915]
GMQ Drug Info [543915]
Blocker APETX2 Drug Info [536309], [537642]
Inhibitor ASIC3 inhibitors Drug Info [543915]
Antagonist THA-902 Drug Info [543915]
Pathways
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome Stimuli-sensing channels
WikiPathways Iron uptake and transport
References
Ref 536309Peptides inhibitors of acid-sensing ion channels. Toxicon. 2007 Feb;49(2):271-84.
Ref 537642Challenges in Analgesic Drug Development. Clin Pharmacol Ther. 2009 Aug 12.
Ref 543913(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 684).
Ref 543915(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 686).

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