Drug Information

Drug General Information
Drug ID
D0T7GQ
Former ID
DNC001570
Drug Name
APETX2
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [467480]
Therapeutic Class
Analgesics
Target and Pathway
Target(s) Acid-sensing ion channel ASIC3 Target Info Blocker [536309], [537642]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome Stimuli-sensing channels
WikiPathways Iron uptake and transport
References
Ref 467480(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4135).
Ref 536309Peptides inhibitors of acid-sensing ion channels. Toxicon. 2007 Feb;49(2):271-84.
Ref 537642Challenges in Analgesic Drug Development. Clin Pharmacol Ther. 2009 Aug 12.

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