Drug Information

Drug General Information
Drug ID
D0G7NW
Former ID
DIB019672
Drug Name
cyamemazine
Synonyms
cyamepromazine; RP-7204
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543105]
Formula
C19H21N3S
InChI
InChI=1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3
InChIKey
SLFGIOIONGJGRT-UHFFFAOYSA-N
PubChem Compound ID
62865
PubChem Substance ID
8188334, 14826280, 43119930, 47285901, 47880135, 50006264, 51091644, 57314886, 75129996, 85209840, 96099841, 104326854, 125824719, 135019180, 135650143, 136158994, 136352157, 137006389, 142677092, 160676424, 162221098, 163133724, 164838618, 164838619, 172919690, 179225635, 184530546, 226509842, 249924678
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Antagonist [526510]
5-hydroxytryptamine 1A receptor Target Info Antagonist [526510]
5-hydroxytryptamine 7 receptor Target Info Antagonist [526510]
5-hydroxytryptamine 2C receptor Target Info Antagonist [526510]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
Serotonergic synapsehsa04014:Ras signaling pathway
Serotonergic synapsehsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 543105(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 84).
Ref 526510Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes. Biochem Pharmacol. 2003 Feb 1;65(3):435-40.

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