Drug Information

Drug General Information
Drug ID
D03XAE
Former ID
DNC004555
Drug Name
[2-(5-Ethyl-1H-indol-3-yl)-ethyl]-dimethyl-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525845]
Formula
C14H20N2
Canonical SMILES
CCC1=CC2=C(C=C1)NC=C2CCN(C)C
InChI
1S/C14H20N2/c1-4-11-5-6-14-13(9-11)12(10-15-14)7-8-16(2)3/h5-6,9-10,15H,4,7-8H2,1-3H3
InChIKey
ZEHXYLDGQMEYAX-UHFFFAOYSA-N
PubChem Compound ID
10775128
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Inhibitor [525845]
5-hydroxytryptamine 1B receptor Target Info Inhibitor [525845]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 525845Bioorg Med Chem Lett. 2000 Aug 7;10(15):1707-9.5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists.
Ref 525845Bioorg Med Chem Lett. 2000 Aug 7;10(15):1707-9.5-Alkyltryptamine derivatives as highly selective and potent 5-HT1D receptor agonists.

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