Drug Information

Drug General Information
Drug ID
D03MVY
Former ID
DNC004434
Drug Name
2-(5-Thiophen-2-yl-1H-indol-3-yl)-ethylamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525792]
Formula
C14H14N2S
Canonical SMILES
C1=CSC(=C1)C2=CC3=C(C=C2)NC=C3CCN
InChI
1S/C14H14N2S/c15-6-5-11-9-16-13-4-3-10(8-12(11)13)14-2-1-7-17-14/h1-4,7-9,16H,5-6,15H2
InChIKey
KULFBKTWESBCBG-UHFFFAOYSA-N
PubChem Compound ID
10198700
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Inhibitor [525792]
5-hydroxytryptamine 1B receptor Target Info Inhibitor [525792]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 525792Bioorg Med Chem Lett. 2000 May 1;10(9):903-5.5-Thienyltryptamine derivatives as serotonin 5-HT1B/1D receptor agonists: potential treatments for migraine.
Ref 525792Bioorg Med Chem Lett. 2000 May 1;10(9):903-5.5-Thienyltryptamine derivatives as serotonin 5-HT1B/1D receptor agonists: potential treatments for migraine.

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