| General Information of MIC (ID: MC1288) |
| MIC Name |
Clostridium hathewayi
|
| Synonym |
Clostridium hathewayi
|
| Lineage |
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Clostridiaceae
Genus: Hungatella
|
| Oxygen Sensitivity |
Obligate anaerobe
|
| Microbial Metabolism |
Saccharolytic; Fermentative
|
| Gram |
Negative
|
| Description |
Clostridium hathewayi is a gram-negative, endospore-forming and rod-shaped bacteria from the genus of Hungatella. Hungatella hathewayi can cause infection in Humans in rare cases.
|
| External Links |
Taxonomy ID |
154046
|
| GutMDisorder ID |
gm0503
|
| GIMICA ID |
MIC00397
|
| Full List of Metabolite(s) Produced by This MIC |
| Molecule Type: Fatty acids |
|---|
| Metabolite Name: Acetate |
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|
| Detailed Infomation |
Meta Info
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|
Metabolic Classification |
Microbial producted compound [end-products] |
| Modification Type |
Molecule |
EM Info |
Cell/Tissue Type |
Modified sites |
Condition |
REF |
| Histone Acetylation |
H3 |
EM Info
|
. |
lysine 9 |
. |
[1], [2] |
| Histone Deacetylation |
HDAC9 |
EM Info
|
. |
. |
. |
[1], [3] |
| Metabolite Name: Butyrate |
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|
| Detailed Infomation |
Meta Info
click to show the detail information of this Metabolite
|
Metabolic Classification |
Microbial producted compound [end-products] |
| Modification Type |
Molecule |
EM Info |
Cell/Tissue Type |
Modified sites |
Condition |
REF |
| Histone Acetylation |
Histone |
EM Info
|
naive CD4+ T cells |
Foxp3 |
inflammatory |
[4], [2] |
| Histone Deacetylation |
HDAC2 |
EM Info
|
. |
. |
. |
[1], [3] |
| Histone Deacetylation |
HDAC1 |
EM Info
|
. |
. |
. |
[1], [3] |
| References |
| 1 |
Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
|
| 2 |
Effect of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation in drinking water on chicken crop and caeca microbiome PLoS One. 2020 Jan 24;15(1):e0228338. doi: 10.1371/journal.pone.0228338. eCollection 2020.
|
| 3 |
Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease Digestion. 2016;93(1):59-65. doi: 10.1159/000441768. Epub 2016 Jan 14.
|
| 4 |
Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
|
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